14115-1-AP

antibody from Proteintech Group

Targeting: UBE2S E2-EPF

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

14115-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14115-1-AP, RRID:AB_2256809

Product name

UBE2S antibody

Antibody type

Polyclonal

Description

KD/KO validated UBE2S antibody (Cat. #14115-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

UBE2S and HIF1α expression patterns and stratified analysis reveal prognostic value in esophageal squamous cell carcinoma.

Ma M, Li M, Lv Y, Zhang Y, Pang X, Ma Y
PeerJ 2026;14:e20694

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Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma.

Li W, Zhou K, Li M, Su L, Liu X, Lv Y, Ma Y
Analytical cellular pathology (Amsterdam) 2025;2025:3557238

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UBE2S inhibits colorectal cancer proliferation by regulating the PI3K/AKT and MAPK/ERK pathways via TRAF6.

Li J, Feng H, Liu K, Huang H, Ji X, Zhang T, Cheng X, Zhao R
Scientific reports 2025 Oct 13;15(1):35610

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Ubiquitin-conjugating enzyme E2S (UBE2S) as a prognostic biomarker and regulator of tumorigenesis in osteosarcoma.

Liu B, Li C, He S, Li Z, Wang H, Feng C, Xiong Z, Tu C, Song D, Li Z
International immunopharmacology 2025 May 8;154:114545

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UBE2S, downregulated by miR-152-3p, facilitates prostate cancer progression through the PTEN-mediated AKT/mTOR pathway.

Wang C, Zhang G, Jiang Y, Bao G, Li C
Human molecular genetics 2025 Mar 7;34(6):523-532

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UBE2S-mediated deubiquitination of GLUT1 via USP10 regulates glucose metabolic reprogramming and immune microenvironment to promote fibrosis in endometriosis.

Wang B, Hu L, Zhang Z, Yin Y, Zheng L, Wu H, Cheng Y, Zhang G
Journal of translational medicine 2025 Dec 5;23(1):1383

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Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2.

Xu L, Wang B, Gang Z, Han Z, Wang A, Liu Q, Liu H, Wei S, Lin Z, Xie C, Hu L
International journal of biological macromolecules 2025 Apr;302:140583

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Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data.

Yuan Z, Zhu Q, Wu Q, Zhang Z, Guo J, Wu G, Zheng C, Xu Q, Huang D, Cui D
Journal of Cancer 2024;15(9):2580-2600

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UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.

Zhang R, Li C, Zhang S, Kong L, Liu Z, Guo Y, Sun Y, Zhang C, Yong Y, Lv J, Lu M, Liu M, Wu D, Zhang T, Yang H, Wei D, Chen Z, Bian H
Clinical and molecular hepatology 2024 Oct;30(4):771-792

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UBE2S facilitates glioblastoma progression through activation of the NF-κB pathway via attenuating K11-linked ubiquitination of AKIP1.

Han Z, Xu L, Wang A, Wang B, Liu Q, Liu H, Liu Q, Gang Z, Yu S, Mu L, Weng C, Lin Z, Hu L
International journal of biological macromolecules 2024 Oct;278(Pt 1):134426

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Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition.

Gliech CR, Yeow ZY, Tapias-Gomez D, Yang Y, Huang Z, Tijhuis AE, Spierings DC, Foijer F, Chung G, Tamayo N, Bahrami-Nejad Z, Collins P, Nguyen TT, Plata Stapper A, Hughes PE, Payton M, Holland AJ
The EMBO journal 2024 Mar;43(5):666-694

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The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.

Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D
Journal of virology 2024 Feb 20;98(2):e0172623

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UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc.

Gong D, Rao X, Min Z, Liu X, Xin H, Zhou P, Yang L, Li D
American journal of cancer research 2023;13(8):3705-3720

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UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

Xiao K, Peng S, Lu J, Zhou T, Hong X, Chen S, Liu G, Li H, Huang J, Chen X, Lin T
Cell death & disease 2023 Jul 8;14(7):408

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UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.

Peng S, Chen X, Huang C, Yang C, Situ M, Zhou Q, Ling Y, Huang H, Huang M, Zhang Y, Cheng L, Zhang Q, Guo Z, Lai Y, Huang J
International journal of biological sciences 2022;18(8):3528-3543

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BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding.

Wang M, Zhao K, Liu M, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T, Wang H, Jiang C, Gao S, Chen J
Protein & cell 2022 Aug;13(8):580-601

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UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway.

Hu W, Li M, Chen Y, Gu X
Journal of ovarian research 2021 Sep 17;14(1):121

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The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.

Xu W, Huang M, Guo J, Zhang H, Wang D, Liu T, Liu H, Chen S, Gao P, Mu K
International journal of biological sciences 2020;16(8):1388-1402

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Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1.

Huang L, Liu H, Zhang K, Meng Q, Hu L, Zhang Y, Xiang Z, Li J, Yang Y, Chen Y, Cui S, Tang H, Pei H, Bu Z, Weng C
Cell reports 2020 Aug 18;32(7):108044

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UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.

Yoshimura S, Kasamatsu A, Nakashima D, Iyoda M, Kasama H, Saito T, Takahara T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K
Biochemical and biophysical research communications 2017 Apr 15;485(4):820-825

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 14115-1-AP(UBE2S antibody) at dilution of 1:500

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 14115-1-AP(UBE2S antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 14115-1-AP(UBE2S antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The UBE2S antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UBE2S. This antibody recognizes human,mouse,rat antigen. The UBE2S antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.

Appendix

14115-1-AP.pdf

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