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- Antigen structure
- References [18]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14755-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14755-1-AP, RRID:AB_2220236
- Product name
- ACAT2 antibody
- Antibody type
- Polyclonal
- Description
- ACAT2 antibody (Cat. #14755-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references 7-dehydrocholesterol promotes CCL2-secretion from porcine skeletal muscle satellite cells, enhancing the migration of preadipocytes.
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.
High-Fat Diet Attenuates the Benefits of Increasing Phospholipid-to-Cholesterol Ratio on Lipid Metabolism in Mice: Evidence From Egg Yolk Low- and High-Density Lipoprotein Intake.
SP600125 decreases cAMP/PKA-dependent steroid production through ATF4/DDIT3 activation in MA-10 Leydig cells.
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones.
Different effects of low- and high-density lipoproteins in egg yolk on lipid metabolism of mouse: Role of phospholipids-to-cholesterol intake ratio.
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer.
Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.
Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells.
HMGB1 contributes to SASH1 methylation to attenuate astrocyte adhesion.
Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.
Oral Administration of Succinoglycan Riclin Improves Diet-Induced Hypercholesterolemia in Mice.
Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo.
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Zhao Y, Yao Y, Wang X, Zhang L, Wei W, Chen J
Biochemical and biophysical research communications 2026 Jan 1;794:153070
Biochemical and biophysical research communications 2026 Jan 1;794:153070
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
Zhang Y, Shao Y, Li X, Zhou D, Zhou J, Yan Q, Gao W, Yang L
Communications biology 2026 Feb 7;9(1)
Communications biology 2026 Feb 7;9(1)
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.
Tan J, Shi C, Wang G, Zhang L, Li F, Yan G, Jin Y, Ding H, Jiang F, Li X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732
High-Fat Diet Attenuates the Benefits of Increasing Phospholipid-to-Cholesterol Ratio on Lipid Metabolism in Mice: Evidence From Egg Yolk Low- and High-Density Lipoprotein Intake.
Zhang F, Ding Y, Ma Y, Li J, Gu L, Chang C, Yang Y, Su Y
Journal of food science 2025 Sep;90(9):e70539
Journal of food science 2025 Sep;90(9):e70539
SP600125 decreases cAMP/PKA-dependent steroid production through ATF4/DDIT3 activation in MA-10 Leydig cells.
Basque A, Izichkis LS, Martin LJ
Molecular and cellular endocrinology 2025 Sep 15;607:112613
Molecular and cellular endocrinology 2025 Sep 15;607:112613
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Chen Y, Yan Q, Ruan S, Cui J, Li Z, Zhang Z, Yang J, Fang J, Liu S, Huang S, Hou B, Zhang C
Cell reports 2025 Jun 24;44(6):115774
Cell reports 2025 Jun 24;44(6):115774
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones.
Rauckhorst AJ, Sheldon RD, Pape DJ, Ahmed A, Falls-Hubert KC, Merrill RA, Brown RF, Deshmukh K, Vallim TA, Deja S, Burgess SC, Taylor EB
Cell metabolism 2025 Jan 7;37(1):255-273.e6
Cell metabolism 2025 Jan 7;37(1):255-273.e6
Different effects of low- and high-density lipoproteins in egg yolk on lipid metabolism of mouse: Role of phospholipids-to-cholesterol intake ratio.
Zhang F, Ma Y, Zhu H, Li J, Gu L, Chang C, Su Y, Yang Y
Journal of food science 2024 Dec;89(12):9751-9765
Journal of food science 2024 Dec;89(12):9751-9765
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.
Fang Y, Kang Z, Zhang W, Xiang Y, Cheng X, Gui M, Fang D
BMC pregnancy and childbirth 2024 Aug 10;24(1):525
BMC pregnancy and childbirth 2024 Aug 10;24(1):525
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E, Xu L
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer.
Zhang E, Ding C, Li S, Aikemu B, Zhou X, Fan X, Sun J, Yang X, Zheng M
Cancer cell international 2023 May 18;23(1):96
Cancer cell international 2023 May 18;23(1):96
Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.
Dalton GD, Oh SH, Tang L, Zhang S, Brown AL, Varadharajan V, Baleanu-Gogonea C, Gogonea V, Pathak P, Brown JM, Diehl AM
iScience 2021 Sep 24;24(9):103089
iScience 2021 Sep 24;24(9):103089
Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells.
Ma C, Chen H, Zhang S, Yan Y, Wu R, Wang Y, Liu Y, Yang L, Liu M
Biochemical and biophysical research communications 2019 Oct 15;518(2):325-330
Biochemical and biophysical research communications 2019 Oct 15;518(2):325-330
HMGB1 contributes to SASH1 methylation to attenuate astrocyte adhesion.
Wu R, Yan Y, Ma C, Chen H, Dong Z, Wang Y, Liu Y, Liu M, Yang L
Cell death & disease 2019 May 28;10(6):417
Cell death & disease 2019 May 28;10(6):417
Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.
Guo Y, Zhao M, Bo T, Ma S, Yuan Z, Chen W, He Z, Hou X, Liu J, Zhang Z, Zhu Q, Wang Q, Lin X, Yang Z, Cui M, Liu L, Li Y, Yu C, Qi X, Wang Q, Zhang H, Guan Q, Zhao L, Xuan S, Yan H, Lin Y, Wang L, Li Q, Song Y, Gao L, Zhao J
Cell research 2019 Feb;29(2):151-166
Cell research 2019 Feb;29(2):151-166
Oral Administration of Succinoglycan Riclin Improves Diet-Induced Hypercholesterolemia in Mice.
Yang Y, Sun Q, Xu X, Yang X, Gao Y, Sun X, Zhao Y, Ding Z, Ge W, Cheng R, Zhang J
Journal of agricultural and food chemistry 2019 Dec 4;67(48):13307-13317
Journal of agricultural and food chemistry 2019 Dec 4;67(48):13307-13317
Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo.
Liu S, You L, Zhao Y, Chang X
Food research international (Ottawa, Ont.) 2018 May;107:73-83
Food research international (Ottawa, Ont.) 2018 May;107:73-83
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130
Cell research 2016 Oct;26(10):1112-1130
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 14755-1-AP(ACAT2 antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 14755-1-AP(ACAT2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ACAT2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACAT2. This antibody recognizes human, mouse, rat antigen. The ACAT2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
