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- Antigen structure
- References [25]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 16888-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16888-1-AP, RRID:AB_2266733
- Product name
- MTCH2 antibody
- Antibody type
- Polyclonal
- Description
- MTCH2 antibody (Cat. #16888-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated multi-omics analysis and experimental investigation of mitochondrial dynamics-related genes: molecular subtypes, immune landscape, and prognostic implications in lung adenocarcinoma.
Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease.
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether.
Benzylurea Protects hPDLFs Against LPS-Induced Mitochondrial Dysfunction Through MTCH2.
MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity.
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolism.
CEAM is a mitochondrial-localized, amyloid-like motif-containing microprotein expressed in human cardiomyocytes.
Brain single-cell transcriptomics highlights comorbidity-related cell type-specific changes of Parkinson's disease with major depressive disorder after paraquat exposure.
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells.
LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membrane.
The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.
APOC1 promotes the progression of osteosarcoma by binding to MTCH2.
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.
MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m(6)A-YTHDF1-dependent mechanism.
Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation.
miR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2.
Wu S, Pan J, Zeng L, Pan Q, Yu Y, Lin J, Zhang J, Jiang Y
Frontiers in immunology 2025;16:1585505
Frontiers in immunology 2025;16:1585505
Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease.
Stephens MC, Li J, Mair M, Moore J, Zhu K, Tarkunde A, Amoh B, Perez AM, Bhakare A, Guo F, Shulman JM, Al-Ramahi I, Botas J
American journal of human genetics 2025 May 1;112(5):1081-1096
American journal of human genetics 2025 May 1;112(5):1081-1096
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Song N, Wang X, Ha L, Hu L, Mei S, Liang Y, Zhao Y, Yang X, Zhang Q, Zhou Y, Ding J, Liu Y, Zhou Q, Han F, Hu G, Lu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2503579
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2503579
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether.
Yang Z, Nakajima S, Chen H, Chakrabarty Y, Feng H, Chan DC
Nature communications 2025 Dec 14;16(1):11260
Nature communications 2025 Dec 14;16(1):11260
Benzylurea Protects hPDLFs Against LPS-Induced Mitochondrial Dysfunction Through MTCH2.
Liu L, Bai J, Wang J, Fan J, Yin D, Chang H, Hui X, Yang P
Oral diseases 2025 Apr;31(4):1255-1267
Oral diseases 2025 Apr;31(4):1255-1267
MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity.
Zhang X, Li E, Kuang Y, Gai Y, Feng Y, Huang Y, Wei Z, Niu J, Yu S, Yang Z, Zhang Q, Sai B, Zhu Y
Cell death & disease 2025 Apr 9;16(1):268
Cell death & disease 2025 Apr 9;16(1):268
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo JA, Harper JW, Shao S
Science advances 2025 Apr 11;11(15):eadu5091
Science advances 2025 Apr 11;11(15):eadu5091
MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolism.
Sun G, Song Y, Li C, Sun B, Li C, Sun J, Xiao P, Zhang Z
Oncology letters 2024 Oct;28(4):492
Oncology letters 2024 Oct;28(4):492
CEAM is a mitochondrial-localized, amyloid-like motif-containing microprotein expressed in human cardiomyocytes.
Li R, Qin T, Guo Y, Zhang S, Guo X
Biochemical and biophysical research communications 2024 Nov 19;734:150737
Biochemical and biophysical research communications 2024 Nov 19;734:150737
Brain single-cell transcriptomics highlights comorbidity-related cell type-specific changes of Parkinson's disease with major depressive disorder after paraquat exposure.
Zhang Y, Jiang Y, Li Y, Yu Z, Lin X, Zheng F, Hu H, Shao W, Yu G, Guo Z, Wu S, Li H
Ecotoxicology and environmental safety 2024 Nov 1;286:117193
Ecotoxicology and environmental safety 2024 Nov 1;286:117193
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Jiang W, Miao Y, Xing X, Liu S, Xing W, Qian F
Heliyon 2024 Mar 30;10(6):e28172
Heliyon 2024 Mar 30;10(6):e28172
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells.
Zhang JW, Huang LY, Li YN, Tian Y, Yu J, Wang XF
World journal of gastrointestinal oncology 2024 Mar 15;16(3):991-1005
World journal of gastrointestinal oncology 2024 Mar 15;16(3):991-1005
LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membrane.
Zhang S, Guo Y, Fidelito G, Robinson DRL, Liang C, Lim R, Bichler Z, Guo R, Wu G, Xu H, Zhou QD, Singh BK, Yen P, Kappei D, Stroud DA, Ho L
iScience 2023 Sep 15;26(9):107558
iScience 2023 Sep 15;26(9):107558
The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
Lenhard S, Gerlich S, Khan A, Rödl S, Bökenkamp JE, Peker E, Zarges C, Faust J, Storchova Z, Räschle M, Riemer J, Herrmann JM
The Journal of cell biology 2023 Oct 2;222(10)
The Journal of cell biology 2023 Oct 2;222(10)
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H
The EMBO journal 2023 Jul 3;42(13):e113033
The EMBO journal 2023 Jul 3;42(13):e113033
Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.
Fischer JA, Monroe TO, Pesce LL, Sawicki KT, Quattrocelli M, Bauer R, Kearns SD, Wolf MJ, Puckelwartz MJ, McNally EM
Human molecular genetics 2023 Jan 1;32(1):15-29
Human molecular genetics 2023 Jan 1;32(1):15-29
APOC1 promotes the progression of osteosarcoma by binding to MTCH2.
Li R, He H, He X
Experimental and therapeutic medicine 2023 Apr;25(4):163
Experimental and therapeutic medicine 2023 Apr;25(4):163
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Labbé K, Mookerjee S, Le Vasseur M, Gibbs E, Lerner C, Nunnari J
The Journal of cell biology 2021 Nov 1;220(11)
The Journal of cell biology 2021 Nov 1;220(11)
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143
RNA biology 2021 Jan;18(1):131-143
Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.
Yuan Q, Yang W, Zhang S, Li T, Zuo M, Zhou X, Li J, Li M, Xia X, Chen M, Liu Y
Molecular medicine (Cambridge, Mass.) 2021 Jan 28;27(1):7
Molecular medicine (Cambridge, Mass.) 2021 Jan 28;27(1):7
MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m(6)A-YTHDF1-dependent mechanism.
Jiang Q, Sun B, Liu Q, Cai M, Wu R, Wang F, Yao Y, Wang Y, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):2971-2981
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):2971-2981
Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation.
Zhang T, Hu Y, Wang T, Cai P
International journal of molecular medicine 2017 Jul;40(1):21-30
International journal of molecular medicine 2017 Jul;40(1):21-30
miR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2.
Arigoni M, Barutello G, Riccardo F, Ercole E, Cantarella D, Orso F, Conti L, Lanzardo S, Taverna D, Merighi I, Calogero RA, Cavallo F, Quaglino E
The American journal of pathology 2013 Jun;182(6):2058-70
The American journal of pathology 2013 Jun;182(6):2058-70
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 16888-1-AP(MTCH2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MTCH2 (IP:16888-1-AP, 3ug; Detection:16888-1-AP 1:1000) with HepG2 cells lysate 4000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16888-1-AP(MTCH2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MTCH2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MTCH2. This antibody recognizes human,mouse,rat antigen. The MTCH2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
