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- Product number
- 17873-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17873-1-AP, RRID:AB_2146587
- Product name
- MMP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MMP3 antibody (Cat. #17873-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial Dynamics Disorder Drives Nucleus Pulposus Cell Senescence in Lumbar Scoliosis of Aging Bipedal Rats Under Asymmetric Force.
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration.
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Psoralen promotes SOCS5 to inhibit JAK/STAT3 to alleviate cartilage degeneration in knee osteoarthritis.
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells.
A Pathological Microenvironment-Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS-Inflammation Cascade to Alleviate Intervertebral Disc Degeneration.
HDAC6 exacerbates osteoarthritis by promoting macrophage inflammation-mediated chondrocyte degeneration.
Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single-Cell Sequencing Analysis.
Integrative Transcriptomic and Machine Learning Analysis Identifies Key Senescence-Associated Secretory Phenotype Genes Associated With Immune Dysregulation in Periodontitis.
Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis.
Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells.
Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes.
Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration.
Mechanistic study of quercetin in the treatment of thyroid cancer with diabetes based on network pharmacology and in vitro experiments.
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Bioinspired exosome-SiO(2) nanohybrid therapeutic for rheumatoid arthritis treatment.
17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway.
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway.
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway.
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.
Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers.
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence.
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic.
NOXA exacerbates endoplasmic-reticulum-stress-induced intervertebral disc degeneration by activating apoptosis and ECM degradation.
Ginsenoside CK and retinol on UVA-induced photoaging exert the synergistic effect through antioxidant and antiapoptotic mechanisms.
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Metalloproteomic analysis of hemophilic arthropathy synovial tissue: insights into metal overload and pathogenesis.
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
The regulatory role of BMP9 on lipopolysaccharide-induced matrix metalloproteinases in human stem cells from the apical papilla.
Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways.
Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways.
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Berberine alleviates tendinopathy by suppressing the cGAS-STING pathway and Relieving ferroptosis.
Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes.
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
MMP3 as a new target of Danshensu/tetramethylpyrazine derivative for attenuating cardiac fibrosis post-myocardial infarction.
Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.
Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing.
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Yanghe decoction alleviates osteoarthritis by AMPK-SIRT3 positive feedback loop-mediated mitochondrial autophagy.
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Synovium-On-A-Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast-Like Synoviocytes.
DDRGK1 preserves intervertebral disc development through ufmylation.
Porphyromonas gingivalis extracellular vesicles promotes tumor metastasis in esophageal squamous cell carcinoma by inducing PRKACB/JNK/ NFATC2 axis.
Expression and Biological Activity of Recombinant Type IV Collagen.
Deciphering the pharmacological mechanisms of salidroside in cervical cancer by combining network pharmacology, molecular docking, and in vitro studies.
Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones.
SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.
Paclitaxel-mediated microtubule stabilization regulates flexor tendon repair in rats.
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration.
Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis.
Spatial transcriptomics and single-cell RNA-sequencing revealed dendritic cell-mediated inflammation in keratoconus.
Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage.
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence.
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Skin organoid transplantation promotes tissue repair with scarless in frostbite.
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes.
Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization.
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
O304 alleviates abdominal aortic aneurysm formation via AMPK/mTOR/MMP pathway activation.
TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease.
Cancer-associated fibroblasts promote the malignant development of lung cancer through the FOXO1 protein/LIF signaling.
Syn-COM: A Multi-Level Predictive Synergy Framework for Innovative Drug Combinations.
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis.
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.
Protective effect and mechanism of lycium barbarum polysaccharide against UVB-induced skin photoaging.
WRN Nuclease-Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles.
Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy.
Mapping and Analysis of Protein and Gene Profile Identification of the Important Role of Transforming Growth Factor Beta in Synovial Invasion in Patients With Pigmented Villonodular Synovitis.
Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration.
Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis.
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Protective effects of sugarcane polyphenol against UV-B-induced photoaging in Balb/c mouse skin: Antioxidant, anti-inflammatory, and anti-glycosylation Effects.
Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3.
M2 Microglial Extracellular Vesicles Attenuated Blood-brain Barrier Disruption via MiR-23a-5p in Cerebral Ischemic Mice.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
The mechanism of action of myricetin against lung adenocarcinoma based on bioinformatics, in silico and in vitro experiments.
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Cordycepin Enhances the Therapeutic Efficacy of Doxorubicin in Treating Triple-Negative Breast Cancer.
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.
Loss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study.
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development.
Esculin Alleviates Osteoarthritis Progression Through the Sirt1/NF-κB Pathway.
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling.
YAP1 exacerbates pyroptosis and senescence in nucleus pulposus cells by promoting BNIP3-mediated mitophagy.
Identifying specific functional roles for senescence across cell types.
Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats.
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
Mechanical overload induces TMJ disc degeneration via TRPV4 activation.
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
GKT137831 in combination with adipose-derived stem cells alleviates high glucose-induced inflammaging and improves diabetic wound healing.
Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study.
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.
The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.
Dendrobium nobile Lindl Polysaccharides Attenuate UVB-induced Photodamage by Regulating Oxidative Stress, Inflammation and MMPs Expression in Mice Model.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
POFUT1 promotes gastric cancer progression through Notch/Wnt dual signaling pathways dependent on the parafibromin-NICD1-β-catenin complex.
Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation.
Nrf3 promotes the proliferation and migration of triple‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition.
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions.
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Combination of hyperlipidemia and 17β-Estradiol induces TMJOA-like pathological changes in rats.
Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis.
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.
Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis.
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Protective effects of Cu/Zn-SOD and Mn-SOD on UVC radiation-induced damage in NIH/3T3 cells and murine skin.
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis.
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation.
Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro.
Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo.
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
FUNDC1/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis.
MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression.
Bauhinia championii alleviates extracellular matrix degradation in IL-1β induced chondrocytes via miRNA-145-5p/TLR4/NF-κB axis.
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Identification of hub genes and pathways in lung metastatic colorectal cancer.
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study.
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway.
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
180-W GreenLight laser photoselective vaporization with multiple triamcinolone acetonide injections for the treatment of bladder neck contractures.
Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Belinostat (PXD101) resists UVB irradiation-induced cellular senescence and skin photoaging.
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Epigenetic Changes within the Annulus Fibrosus by DNA Methylation in Rat Intervertebral Disc Degeneration Model.
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.
Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling.
Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.
Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints.
The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells.
Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase.
PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer.
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.
Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
An impaired healing model of osteochondral defect in papain-induced arthritis.
GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis.
Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1β expression in mononuclear cells.
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Gut microbiota regulate tumor metastasis via circRNA/miRNA networks.
lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells.
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL-1β-Treated Rat Chondrocytes via Suppressing MAPK and NF-κB Signaling Pathways.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Tumor-associated macrophages (TAMs) depend on Shp2 for their anti-tumor roles in colorectal cancer.
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Cx43-Associated Secretome and Interactome Reveal Synergistic Mechanisms for Glioma Migration and MMP3 Activation.
Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3.
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats.
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype.
Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis.
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.
A mechanism of regucalcin knock-down in the promotion of proliferation and movement of human cervical cancer HeLa cells.
Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Tumor cell density regulates matrix metalloproteinases for enhanced migration.
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression.
Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells.
Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions.
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.
18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration.
Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease.
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.
Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma.
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs.
Matrix metalloproteinase 3 promotes cellular anti-dengue virus response via interaction with transcription factor NFκB in cell nucleus.
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.
Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC).
Rho GDP dissociation inhibitor beta promotes cell proliferation and invasion by modulating the AKT pathway in hepatocellular carcinoma.
Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo.
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes.
CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2.
Wang J, Cao D, Peng J, Zhou X, Liu Z, Wang X, Zhang A, Shen K
Stem cells international 2026;2026:1581661
Stem cells international 2026;2026:1581661
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration.
Wu W, Cheng Z, Shi P, Gao H, Chen X, Wu W, Yu Z, Yang C, Zhang Y
Bioactive materials 2026 Jul;61:555-576
Bioactive materials 2026 Jul;61:555-576
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Wu L, Tao Y, Xu Y, Liang Z, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Psoralen promotes SOCS5 to inhibit JAK/STAT3 to alleviate cartilage degeneration in knee osteoarthritis.
Zhang J, Tian J, Weiyang W, Yang Y, Li Y, Ye X, Huang D, Xu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157643
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157643
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Luo J, Yu T, Hu P, Liu J
Non-coding RNA research 2026 Apr;17:76-89
Non-coding RNA research 2026 Apr;17:76-89
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells.
Wang X, Sun H, Xiao W, Zhang Y, Lu X, Gong Z, Li D, Liu S, Xia X, Wang H, Shao M, Xu G, Ma X
Non-coding RNA research 2026 Apr;17:112-127
Non-coding RNA research 2026 Apr;17:112-127
A Pathological Microenvironment-Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS-Inflammation Cascade to Alleviate Intervertebral Disc Degeneration.
Luo X, Xie J, Yan F, Peng Z, Pan C, Hu Y, Zhang J, Cai C, Yuan J, Li Y, Miao X, He D, Cheng X
Advanced healthcare materials 2026 Apr 14;:e71151
Advanced healthcare materials 2026 Apr 14;:e71151
HDAC6 exacerbates osteoarthritis by promoting macrophage inflammation-mediated chondrocyte degeneration.
Wang S, Fu L, Qiu W, Ouyang J, Song D, Song Z, Zhu Y, Yan Z, Jin F, Lu YJ, Liu G
International immunopharmacology 2026 Apr 1;174:116399
International immunopharmacology 2026 Apr 1;174:116399
Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single-Cell Sequencing Analysis.
Liu C, Jiao K, Li X, Deng Z, Wang S, Cheng Y, Li M, Zhou X, Wei X
Mediators of inflammation 2025;2025:5593429
Mediators of inflammation 2025;2025:5593429
Integrative Transcriptomic and Machine Learning Analysis Identifies Key Senescence-Associated Secretory Phenotype Genes Associated With Immune Dysregulation in Periodontitis.
Zeng J, Huang J, He J, Tan J, Duan M, Song Y, Yang L
Human mutation 2025;2025:3637248
Human mutation 2025;2025:3637248
Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis.
Li H, Chen X, Huang B, He J, Xie J, Guo W, Liang J, Ruan J, Liu J, Xiang Z, Zhu L
Open life sciences 2025;20(1):20220913
Open life sciences 2025;20(1):20220913
Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells.
Zhao R, Ma L, Li J, Liu S, Yang D, Liu G, Yang S
International journal of nanomedicine 2025;20:2411-2425
International journal of nanomedicine 2025;20:2411-2425
Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes.
Johansen CG, Lam K, Farnsworth NL
Frontiers in endocrinology 2025;16:1675043
Frontiers in endocrinology 2025;16:1675043
Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration.
Zhang H, Dai B, Peng J, Gao M, Li D, Xiang X, Zhu J
Frontiers in immunology 2025;16:1671961
Frontiers in immunology 2025;16:1671961
Mechanistic study of quercetin in the treatment of thyroid cancer with diabetes based on network pharmacology and in vitro experiments.
Liu S, Cai Y, Chen W, Yuan X, He Z, Lin F
Frontiers in endocrinology 2025;16:1537799
Frontiers in endocrinology 2025;16:1537799
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X
Frontiers in pharmacology 2025;16:1501725
Frontiers in pharmacology 2025;16:1501725
Bioinspired exosome-SiO(2) nanohybrid therapeutic for rheumatoid arthritis treatment.
Zhu Q, Chen R, Wu X, Zhou Y, Wang Z, Zhang H, Zhu H, Sun L, Shuai Z
Theranostics 2025;15(13):6553-6571
Theranostics 2025;15(13):6553-6571
17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway.
Liu T, Li Z, Zhang W, Guo X, Liu G, Yang D, Yang S
Frontiers in cell and developmental biology 2025;13:1564458
Frontiers in cell and developmental biology 2025;13:1564458
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway.
Ren S, Zeng W, Du Z, Dai J, Li X, Wang H, Liu Y, Li R, Liu J
Journal of natural medicines 2025 Sep;79(5):1030-1043
Journal of natural medicines 2025 Sep;79(5):1030-1043
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway.
Wu B, Luo Z, Chen Z, Lu Y, Duan J, Yang Z, Lu G
International immunopharmacology 2025 Sep 23;162:115111
International immunopharmacology 2025 Sep 23;162:115111
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.
Peng Y, Huang YH, Luo X, Li MC, Xiao QQ, Qiu L, Fu Q
Journal of Asian natural products research 2025 Oct;27(10):1528-1549
Journal of Asian natural products research 2025 Oct;27(10):1528-1549
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Ran R, Gong CY, Wu ZL, Zhang SB, Zhang K, Zhou WM, Song W, Dong H, Shi YQ, Zhou KS, Zhang HH
The American journal of pathology 2025 Oct;195(10):1905-1920
The American journal of pathology 2025 Oct;195(10):1905-1920
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.
Li J, Tang H, Chang H, Du Y, Du L, Zhao E
Cell death & disease 2025 Oct 21;16(1):737
Cell death & disease 2025 Oct 21;16(1):737
Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers.
Ma L, Chen J, Li Q, Zhu Y, Ren S, Song K, Yao Z, Yang X, Zheng Y, Liu Z, Wang Z, Miao K, Chen S, Zhao XY, Luo F
Cell death discovery 2025 Nov 6;11(1):505
Cell death discovery 2025 Nov 6;11(1):505
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Wang Y, Tan L, Yang Y, Duan H, Liu C, Zhao J, Zhou Y, Li C, Liu M
Nature communications 2025 Nov 20;16(1):11253
Nature communications 2025 Nov 20;16(1):11253
Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence.
Han S, Zhu W, Guo Q
Current eye research 2025 May;50(5):467-476
Current eye research 2025 May;50(5):467-476
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic.
Xu C, Zhou X, Yang C, Zhou F, Xie Y
Biomedicines 2025 May 30;13(6)
Biomedicines 2025 May 30;13(6)
NOXA exacerbates endoplasmic-reticulum-stress-induced intervertebral disc degeneration by activating apoptosis and ECM degradation.
Liu Z, Lu H, Zhang X, Tang S, Lin A, Han S, Ma X
Cell death discovery 2025 May 28;11(1):257
Cell death discovery 2025 May 28;11(1):257
Ginsenoside CK and retinol on UVA-induced photoaging exert the synergistic effect through antioxidant and antiapoptotic mechanisms.
Zhang J, Li Z, Song X, Cai P, Liu Q
Scientific reports 2025 May 13;15(1):16664
Scientific reports 2025 May 13;15(1):16664
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Liu Q, Wang F, Du Y, Liu Y, Zhang Z, Zhang X, Li J, Huang G, Liu F, Li B, Xiao W, Sui C, Bao N, Zhuang R, Gao C, Wang X, Gu X
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Metalloproteomic analysis of hemophilic arthropathy synovial tissue: insights into metal overload and pathogenesis.
Luo D, Zheng L, Ding M, Yu D, Chen T, Zheng K, Jing J, Yao Y
Journal of thrombosis and haemostasis : JTH 2025 Mar;23(3):888-902
Journal of thrombosis and haemostasis : JTH 2025 Mar;23(3):888-902
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Feng X, Ma Y, Zhao Y, Zhao Z, Song Z, Lin L, Wang W
Molecular immunology 2025 Mar;179:94-105
Molecular immunology 2025 Mar;179:94-105
The regulatory role of BMP9 on lipopolysaccharide-induced matrix metalloproteinases in human stem cells from the apical papilla.
Wang G, Yi Q, Hu B, Peng M, Fu T, Huang E
Archives of oral biology 2025 Mar;171:106154
Archives of oral biology 2025 Mar;171:106154
Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways.
Dai Q, Wang Z, Wang X, Lian W, Ge Y, Song S, Li F, Zhao B, Li L, Wang X, Zhou M, Cheng J
Scientific reports 2025 Mar 29;15(1):10905
Scientific reports 2025 Mar 29;15(1):10905
Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways.
Hu H, Xie T
Cell biochemistry and biophysics 2025 Jun;83(2):2009-2021
Cell biochemistry and biophysics 2025 Jun;83(2):2009-2021
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
Tu M, Liu AM, Huang W, Wang D, Chen HQ, Hu XY
Journal of cell communication and signaling 2025 Jun;19(2):e70008
Journal of cell communication and signaling 2025 Jun;19(2):e70008
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.
Cao J, Zhang H, Ni Y, Ning X
Molecular immunology 2025 Jun;182:117-125
Molecular immunology 2025 Jun;182:117-125
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Gan X, Li J, Jiang Y, Wang X, Zeng Y, Chen X, Huang H, Min J, Li G, Nie M, Kang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Berberine alleviates tendinopathy by suppressing the cGAS-STING pathway and Relieving ferroptosis.
Shen Y, Wei W, Lu Y, Song M, Yang S, Liu H, Xu X, Zhou H
Biochemical and biophysical research communications 2025 Jun 30;767:151923
Biochemical and biophysical research communications 2025 Jun 30;767:151923
Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes.
Johansen CG, Lam K, Farnsworth NL
bioRxiv : the preprint server for biology 2025 Jun 27;
bioRxiv : the preprint server for biology 2025 Jun 27;
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62
Bone research 2025 Jun 12;13(1):62
MMP3 as a new target of Danshensu/tetramethylpyrazine derivative for attenuating cardiac fibrosis post-myocardial infarction.
Huang W, He C, In Kim H, Gao X, You J, Shao T, Liu Y, Wei H, Wang Y, Wang J, Xu Y, Guo J
Life sciences 2025 Jun 1;370:123570
Life sciences 2025 Jun 1;370:123570
Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway.
Qin YY, Qin ZY, Liang T, Qin DE, Hua SY, Tan MH, Guo S, Yang F, Shi L, Yu Y, Zhang GJ
Immunobiology 2025 Jul;230(4):152918
Immunobiology 2025 Jul;230(4):152918
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.
Zhao H, Jiang F, Zhang P, Bi Y, Shen Y, Ma J, Gong J, Han K, Zhang L, Yu T, Xiao X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70799
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70799
Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing.
Fu Y, Xie JL, Zhang XL, Xie GM, Zhang XM, Han YT, Xu MM, Zhang J, Zhang J
Journal of nanobiotechnology 2025 Jul 14;23(1):506
Journal of nanobiotechnology 2025 Jul 14;23(1):506
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
Liu Y, Nie M, Li X, Wang H, Ren S, Zou D, Liu J, Li R
Applied biochemistry and biotechnology 2025 Jan;197(1):518-533
Applied biochemistry and biotechnology 2025 Jan;197(1):518-533
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Xu J, Wang G, Hou Y, Sun K, Zheng Z, Guo Z, Hou L, Zhang X, Ruan Z, Ye Y, Guo F
International immunopharmacology 2025 Jan 10;144:113681
International immunopharmacology 2025 Jan 10;144:113681
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Liu Z, Sun T, Zhang Z, Piao C, Kong C, Zhang X
Clinical and translational medicine 2025 Feb;15(2):e70232
Clinical and translational medicine 2025 Feb;15(2):e70232
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Fu H, Wu S, Shen H, Luo K, Huang Z, Lu N, Li Y, Lan Q, Xian Y
Heliyon 2025 Feb 15;11(3):e42095
Heliyon 2025 Feb 15;11(3):e42095
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Xu H, Wei K, Ni J, Deng X, Wang Y, Xiang T, Song F, Wang Q, Niu Y, Jiang F, Wang J, Sheng L, Dai J
Bone research 2025 Feb 14;13(1):23
Bone research 2025 Feb 14;13(1):23
Yanghe decoction alleviates osteoarthritis by AMPK-SIRT3 positive feedback loop-mediated mitochondrial autophagy.
Shi PB, Du MM, Yu P, Bu XZ, Meng DF, Qiao WP, Wang LH, Li HY
Journal of ethnopharmacology 2025 Feb 11;341:119294
Journal of ethnopharmacology 2025 Feb 11;341:119294
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Gan X, Li J, Li S, Wang X, Wang Q, Chen X, Huang Y, Nie M, Kang H, Dai H
Materials today. Bio 2025 Dec;35:102359
Materials today. Bio 2025 Dec;35:102359
Synovium-On-A-Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast-Like Synoviocytes.
Diao W, Jiao Y, Deng T, Gu J, Wang B, Zhang Q, Wang P, Xu N, Xiao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e11945
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e11945
DDRGK1 preserves intervertebral disc development through ufmylation.
Lu M, Zhou T, Yang X, Liu K, Rong K, Ma P, Qin A, Zhao J
Cellular and molecular life sciences : CMLS 2025 Dec 29;83(1):47
Cellular and molecular life sciences : CMLS 2025 Dec 29;83(1):47
Porphyromonas gingivalis extracellular vesicles promotes tumor metastasis in esophageal squamous cell carcinoma by inducing PRKACB/JNK/ NFATC2 axis.
Hong K, Zhang H, Qi J, Zhang J, Yin H, Song Q, Wan P, Yu B
Journal of nanobiotechnology 2025 Dec 19;24(1):66
Journal of nanobiotechnology 2025 Dec 19;24(1):66
Expression and Biological Activity of Recombinant Type IV Collagen.
Chang Y, Zhang Z, Yuwen W, Xu R, Fu R, Zhu C, Li W, Duan Z, Fan D
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31865-31877
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31865-31877
Deciphering the pharmacological mechanisms of salidroside in cervical cancer by combining network pharmacology, molecular docking, and in vitro studies.
Wang J, Song G, Hussain L, Xing L
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2025 Dec 15;33(6):49
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2025 Dec 15;33(6):49
Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.
Zhou R, Wang X, Jin Y, Chen B, Liu H, Zhao X, Jing D, Zhao B
Free radical biology & medicine 2025 Dec 1;240:457-471
Free radical biology & medicine 2025 Dec 1;240:457-471
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones.
Zhang Z, Huang Y, Hu X, Mu Y, Zhou H, Ma L, Liu B, Yao H, Jiang X, Wang DA
Bioactive materials 2025 Aug;50:364-381
Bioactive materials 2025 Aug;50:364-381
SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.
Dong L, Yang Z, Liu J, Wu R, Liao Y, Kuang L
Cellular signalling 2025 Aug;132:111840
Cellular signalling 2025 Aug;132:111840
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.
Lv Q, Zhao X, Teng S, Jin X, Zhou Y, Sun Y, Pei H, Yan Z, Ma C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03939
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03939
Paclitaxel-mediated microtubule stabilization regulates flexor tendon repair in rats.
Yang JJ, Xu SW, Zhang XY, Mao WF, Wu YF
Bone & joint research 2025 Aug 6;14(8):685-695
Bone & joint research 2025 Aug 6;14(8):685-695
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration.
Zhao L, Liang K, Cheng W, Zhou X, Yang L, Mao X, Qi W, Jin H, Zhang W, Pan H, Wang D
Nature communications 2025 Aug 26;16(1):7936
Nature communications 2025 Aug 26;16(1):7936
Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis.
Liao T, Kang J, Ma Z, Jie L, Feng M, Liu D, Mao J, Wang P, Xing R
Phytotherapy research : PTR 2025 Apr;39(4):1758-1775
Phytotherapy research : PTR 2025 Apr;39(4):1758-1775
Spatial transcriptomics and single-cell RNA-sequencing revealed dendritic cell-mediated inflammation in keratoconus.
Luo S, Li J, Yang Y, Jiang Y, Jie Y, Ge W
The ocular surface 2025 Apr;36:134-150
The ocular surface 2025 Apr;36:134-150
Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage.
Nam J, Woo H, Yang J, Kim SJ, Lee KP, Yu JH, Park TJ, Eyun SI, Yang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2404311
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2404311
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Hu X, Xie J, Su J
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Journal of nanobiotechnology 2025 Apr 5;23(1):276
TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence.
Chen Y, Zhou T, Zhou R, Sun W, Li Y, Zhou Q, Xu D, Zhao Y, Hu P, Liang J, Zhang Y, Zhong B, Yao J, Jing D
Journal of experimental & clinical cancer research : CR 2025 Apr 4;44(1):112
Journal of experimental & clinical cancer research : CR 2025 Apr 4;44(1):112
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Zhang Y, Ding Y, Liang J, Zhang K, Su H, Wang D, Zhang M, Zhao F, Sun Z, Wu Z, Wang F, Cao G, Zhang Y
International journal of molecular sciences 2025 Apr 20;26(8)
International journal of molecular sciences 2025 Apr 20;26(8)
Skin organoid transplantation promotes tissue repair with scarless in frostbite.
Wang W, Liu P, Zhu W, Li T, Wang Y, Wang Y, Li J, Ma J, Leng L
Protein & cell 2025 Apr 18;16(4):240-259
Protein & cell 2025 Apr 18;16(4):240-259
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Zhou X, Zhu D, Wu D, Li G, Liang H, Zhang W, Wu Y, Xu H, Zhang Z, Tong B, Song Y, Wang K, Feng X, Lei J, Wang H, Zhang X, Ma L, Chen Y, Wei J, Ou Z, Peng S, Wu X, Tan L, Wang B, Yang C
Cell reports. Medicine 2025 Apr 15;6(4):102079
Cell reports. Medicine 2025 Apr 15;6(4):102079
Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.
Lu M, Lou A, Gao J, Li S, He L, Fan W, Zhao L
Journal of orthopaedic surgery and research 2025 Apr 15;20(1):373
Journal of orthopaedic surgery and research 2025 Apr 15;20(1):373
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Gao XF, Ji BY, Zhang JJ, Wang Z, Jiang S, Hu JN, Gong XJ, Zhang JT, Tsopmejio ISN, Li W
The American journal of Chinese medicine 2024;52(5):1427-1449
The American journal of Chinese medicine 2024;52(5):1427-1449
Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes.
Park DR, Choi BR, Yeo C, Yoon JE, Hong EY, Baek SH, Lee YJ, Ha IH
PloS one 2024;19(5):e0302906
PloS one 2024;19(5):e0302906
Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization.
Wang Y, Li Y, Zhou Y, Gao Y, Zhao L
Drug design, development and therapy 2024;18:4183-4202
Drug design, development and therapy 2024;18:4183-4202
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
Guo X, Feng X, Yang Y, Zhang H, Bai L
Frontiers in immunology 2024;15:1462777
Frontiers in immunology 2024;15:1462777
O304 alleviates abdominal aortic aneurysm formation via AMPK/mTOR/MMP pathway activation.
Sun D, Du Y
Frontiers in pharmacology 2024;15:1457817
Frontiers in pharmacology 2024;15:1457817
TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease.
Zhang Q, Wang W, Xiang B, Lin D, Hu J, Zhao J, Lin J, Liu T, Deng J, Zhang M, Zhi M
Gastroenterology report 2024;12:goae103
Gastroenterology report 2024;12:goae103
Cancer-associated fibroblasts promote the malignant development of lung cancer through the FOXO1 protein/LIF signaling.
Shen J, Wu W, Zhang X, Xie X, Shen W, Wang Q
International journal of biological macromolecules 2024 Sep;276(Pt 2):133987
International journal of biological macromolecules 2024 Sep;276(Pt 2):133987
Syn-COM: A Multi-Level Predictive Synergy Framework for Innovative Drug Combinations.
Shi Y, Liu J, Guan S, Wang S, Yu C, Yu Y, Li B, Zhang Y, Yang W, Wang Z
Pharmaceuticals (Basel, Switzerland) 2024 Sep 18;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Sep 18;17(9)
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis.
Li J, Li Y, Shang X, Xu S, Zhang Z, Xu S, Wang X, Shen M
Materials today. Bio 2024 Oct;28:101202
Materials today. Bio 2024 Oct;28:101202
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.
Zhang TL, Chen WK, Huang XP, Zheng BW, Wu PF, Zheng BY, Jiang LX, Escobar D, Li J, Lv GH, Huang W, Zhou H, Xu Z, Zou MX
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18
Protective effect and mechanism of lycium barbarum polysaccharide against UVB-induced skin photoaging.
Fan L, Luan X, Jia Y, Ma L, Wang Z, Yang Y, Chen Q, Cui X, Luo D
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2024 Oct;23(10):1931-1943
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2024 Oct;23(10):1931-1943
WRN Nuclease-Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles.
Li Y, Huang X, Li Y, Qiao Q, Chen C, Chen Y, Zhong W, Liu H, Sun T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2407026
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2407026
Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy.
Wang J, Jing X, Liu X, Chen F, Ge Z, Liu X, Yang H, Guo Y, Cui X
International immunopharmacology 2024 Oct 25;140:112801
International immunopharmacology 2024 Oct 25;140:112801
Mapping and Analysis of Protein and Gene Profile Identification of the Important Role of Transforming Growth Factor Beta in Synovial Invasion in Patients With Pigmented Villonodular Synovitis.
Li T, Xiong Y, Li J, Tang X, Zhong Y, Tang Z, Zhang Q, Luo Y
Arthritis & rheumatology (Hoboken, N.J.) 2024 Nov;76(11):1679-1695
Arthritis & rheumatology (Hoboken, N.J.) 2024 Nov;76(11):1679-1695
Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration.
Zeng P, Zheng X, Zhang H, Zhou M, Chen Z, Song H, Xu W
Applied biochemistry and biotechnology 2024 Nov;196(11):8134-8155
Applied biochemistry and biotechnology 2024 Nov;196(11):8134-8155
Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis.
Li Y, Li J, Xu S, Li D, Zhang Z, Huang Q, Wang X, Shen M, Xu S
Advanced healthcare materials 2024 Nov;13(28):e2401452
Advanced healthcare materials 2024 Nov;13(28):e2401452
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Hua W, Xie L, Dong C, Yang G, Chi S, Xu Z, Yang C, Wang H, Wu X
Journal of translational medicine 2024 Nov 27;22(1):1071
Journal of translational medicine 2024 Nov 27;22(1):1071
Protective effects of sugarcane polyphenol against UV-B-induced photoaging in Balb/c mouse skin: Antioxidant, anti-inflammatory, and anti-glycosylation Effects.
Wang J, Wang M, Zhang C, Li W, Zhang T, Zhou Y, Flavel M, Xi Y, Li H, Liu X
Journal of food science 2024 May;89(5):3048-3063
Journal of food science 2024 May;89(5):3048-3063
Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3.
Zhang Z, Bao Y, Wei P, Yan X, Qiu Q, Qiu L
Oral diseases 2024 May;30(4):2410-2424
Oral diseases 2024 May;30(4):2410-2424
M2 Microglial Extracellular Vesicles Attenuated Blood-brain Barrier Disruption via MiR-23a-5p in Cerebral Ischemic Mice.
Pan JJ, Qi L, Wang L, Liu C, Song Y, Mamtilahun M, Hu X, Li Y, Chen X, Khan H, Xu Q, Wang Y, Tang Y, Yang GY, Zhang Z
Aging and disease 2024 May 7;15(3):1344-1356
Aging and disease 2024 May 7;15(3):1344-1356
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Lu P, Li S, Zhang C, Jiang X, Xiang J, Xu H, Dong J, Wang K, Shi Y
European journal of histochemistry : EJH 2024 May 22;68(2)
European journal of histochemistry : EJH 2024 May 22;68(2)
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123
Bone & joint research 2024 Mar 7;13(3):110-123
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
The mechanism of action of myricetin against lung adenocarcinoma based on bioinformatics, in silico and in vitro experiments.
Hao P, Zhang C, Bian H, Li Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4089-4104
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4089-4104
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Wang Y, Wang S, Wang Y, Wang C, Tang Y, Zhang C, Hou S, Yu D, Lin N
Cellular signalling 2024 Jun;118:111137
Cellular signalling 2024 Jun;118:111137
Cordycepin Enhances the Therapeutic Efficacy of Doxorubicin in Treating Triple-Negative Breast Cancer.
Huang H, Li X, Wu W, Liu C, Shao Y, Wu X, Fu J
International journal of molecular sciences 2024 Jun 27;25(13)
International journal of molecular sciences 2024 Jun 27;25(13)
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.
Li HM, Che X, Tong Z, Wei W, Teng C
ACS omega 2024 Jun 25;9(25):27017-27029
ACS omega 2024 Jun 25;9(25):27017-27029
Loss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma.
Zhang Y, Chang L, Huang P, Cao M, Hong R, Zhao X, He X, Xu L
Molecular carcinogenesis 2024 Jul;63(7):1235-1247
Molecular carcinogenesis 2024 Jul;63(7):1235-1247
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.
Zhou H, He J, Liu R, Cheng J, Yuan Y, Mao W, Zhou J, He H, Liu Q, Tan W, Shuai C, Deng Y
Bioactive materials 2024 Jul;37:51-71
Bioactive materials 2024 Jul;37:51-71
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Zhou J, Li X, Han Z, Qian Y, Bai L, Han Q, Gao M, Xue Y, Geng D, Yang X, Hao Y
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.
Ruan H, Zhu T, Wang T, Guo Y, Liu Y, Zheng J
International journal of molecular sciences 2024 Jul 7;25(13)
International journal of molecular sciences 2024 Jul 7;25(13)
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study.
Jo HG, Baek CY, Hwang Y, Baek E, Song HS, Lee D
Nutrients 2024 Jul 26;16(15)
Nutrients 2024 Jul 26;16(15)
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X
Chemical biology & drug design 2024 Jan;103(1):e14382
Chemical biology & drug design 2024 Jan;103(1):e14382
Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis.
Chen S, Kang P, Zhao Z, Zhang H, Li J, Xu K, Gong D, Jiao F, Wang H, Zhang M
Aging 2024 Jan 8;16(1):648-664
Aging 2024 Jan 8;16(1):648-664
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development.
Hong Q, Liu ZX, Liang HF, Wu DG, Chen Y, Yu B
Journal of orthopaedic surgery and research 2024 Feb 2;19(1):111
Journal of orthopaedic surgery and research 2024 Feb 2;19(1):111
Esculin Alleviates Osteoarthritis Progression Through the Sirt1/NF-κB Pathway.
Sun T, Bai B, Wu H, Xing H, Li J
Phytotherapy research : PTR 2024 Dec;38(12):5793-5805
Phytotherapy research : PTR 2024 Dec;38(12):5793-5805
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling.
Guo Y, Wang P, Hu B, Wang L, Zhang Y, Wang J
International immunopharmacology 2024 Dec 5;142(Pt A):112948
International immunopharmacology 2024 Dec 5;142(Pt A):112948
YAP1 exacerbates pyroptosis and senescence in nucleus pulposus cells by promoting BNIP3-mediated mitophagy.
Peng X, Ji HY, Gao JW, Hong SH, Zhang T, Yang G, Wu X, Gao Y, Wang K
International immunopharmacology 2024 Dec 25;143(Pt 2):113434
International immunopharmacology 2024 Dec 25;143(Pt 2):113434
Identifying specific functional roles for senescence across cell types.
Zhao H, Liu Z, Chen H, Han M, Zhang M, Liu K, Jin H, Liu X, Shi M, Pu W, Werner M, Meister M, Kauschke SG, Sun R, Wang J, Shen R, Wang QD, Ma X, Tchorz JS, Zhou B
Cell 2024 Dec 12;187(25):7314-7334.e21
Cell 2024 Dec 12;187(25):7314-7334.e21
Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration.
Huang Z, Shen X, Chen H, Zhu Z, Lu B, Zhang L, Liu Y, Li Y, Xu B
Heliyon 2024 Aug 15;10(15):e34715
Heliyon 2024 Aug 15;10(15):e34715
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats.
Jing SZ, Yang SH, Qu YK, Hao HH, Wu H
Current medical science 2024 Apr;44(2):355-368
Current medical science 2024 Apr;44(2):355-368
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
Zhao C, Yu Y, Yin G, Xu C, Wang J, Wang L, Zhao G, Ni S, Zhang H, Zhou B, Wang Y
Inflammopharmacology 2024 Apr;32(2):1277-1294
Inflammopharmacology 2024 Apr;32(2):1277-1294
Mechanical overload induces TMJ disc degeneration via TRPV4 activation.
Cui SJ, Yang FJ, Wang XD, Mao ZB, Gu Y
Oral diseases 2024 Apr;30(3):1416-1428
Oral diseases 2024 Apr;30(3):1416-1428
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, Cai Y, Wu C, Chen J, Ruan G, Ding C
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
Xiang Q, Qu L, Lei H, Duan Z, Zhu C, Yuwen W, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
GKT137831 in combination with adipose-derived stem cells alleviates high glucose-induced inflammaging and improves diabetic wound healing.
Dong Y, Zhang Y, Li F, Tang B, Lv D, Wang H, Luo S
Journal of leukocyte biology 2024 Apr 29;115(5):882-892
Journal of leukocyte biology 2024 Apr 29;115(5):882-892
Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases.
Liou GY, Byrd CJ, Storz P, Messex JK
International journal of molecular sciences 2024 Apr 26;25(9)
International journal of molecular sciences 2024 Apr 26;25(9)
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study.
Huang S, Qu M, Chen X, Yu S, Kong F
Frontiers in oncology 2023;13:1174848
Frontiers in oncology 2023;13:1174848
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z, Yang W, Yang H, Zhou Z
The American journal of pathology 2023 Sep;193(9):1234-1247
The American journal of pathology 2023 Sep;193(9):1234-1247
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Wang D, Shang Q, Mao J, Gao C, Wang J, Wang D, Wang H, Jia H, Peng P, Du M, Luo Z, Yang L
Autophagy 2023 Sep;19(9):2485-2503
Autophagy 2023 Sep;19(9):2485-2503
Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.
Li J, Li X, Zhou S, Wang Y, Ying T, Wang Q, Wu Y, Zhao F
Clinical and translational medicine 2023 Sep;13(9):e1415
Clinical and translational medicine 2023 Sep;13(9):e1415
The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.
Li Y, Li H, Wang L, Xie W, Yuan D, Wen Z, Zhang T, Lai J, Xiong Z, Shan Y, Jiang W
International immunopharmacology 2023 Sep;122:110518
International immunopharmacology 2023 Sep;122:110518
Dendrobium nobile Lindl Polysaccharides Attenuate UVB-induced Photodamage by Regulating Oxidative Stress, Inflammation and MMPs Expression in Mice Model.
Long Y, Wang W, Zhang Y, Zhang S, Li Z, Deng J, Li J
Photochemistry and photobiology 2023 Sep-Oct;99(5):1269-1281
Photochemistry and photobiology 2023 Sep-Oct;99(5):1269-1281
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
POFUT1 promotes gastric cancer progression through Notch/Wnt dual signaling pathways dependent on the parafibromin-NICD1-β-catenin complex.
Dong S, Wang Z, Xiong W
Journal of the Chinese Medical Association : JCMA 2023 Sep 1;86(9):806-817
Journal of the Chinese Medical Association : JCMA 2023 Sep 1;86(9):806-817
Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation.
Qian X, Zhu L, Xu M, Liu H, Yu X, Shao Q, Qin J
Chemico-biological interactions 2023 Sep 1;382:110588
Chemico-biological interactions 2023 Sep 1;382:110588
Nrf3 promotes the proliferation and migration of triple‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition.
Chen WM, Hu QY, Hou W, Chen MW, Chen YH, Tang JC
Oncology letters 2023 Oct;26(4):443
Oncology letters 2023 Oct;26(4):443
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Wang D, Zhang L, He D, Zhang Y, Bao J, Gao W, Cheng W, Zhu C, Jin H, Zhang W, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation.
Duan Z, Jin C, Deng Y, Liu J, Gu C, Wang J, Cai X, Li S, Zhou Y
Journal of ethnopharmacology 2023 Oct 5;314:116553
Journal of ethnopharmacology 2023 Oct 5;314:116553
Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions.
Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB
Nature communications 2023 Oct 18;14(1):6582
Nature communications 2023 Oct 18;14(1):6582
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q
Heliyon 2023 Nov;9(11):e21282
Heliyon 2023 Nov;9(11):e21282
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Xu W, Li F, Zhu L, Cheng M, Cheng Y
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Combination of hyperlipidemia and 17β-Estradiol induces TMJOA-like pathological changes in rats.
Zhao Y, Gan YH
Oral diseases 2023 Nov;29(8):3640-3653
Oral diseases 2023 Nov;29(8):3640-3653
Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis.
Wu Y, Ying J, Zhu X, Xu C, Wu L
International immunopharmacology 2023 Nov;124(Pt A):110854
International immunopharmacology 2023 Nov;124(Pt A):110854
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Guo D, Pan H, Lu X, Chen Z, Zhou L, Chen S, Huang J, Liang X, Xiao Z, Zeng H, Shao Y, Qi W, Xie D, Lin C
Arthritis research & therapy 2023 Nov 9;25(1):217
Arthritis research & therapy 2023 Nov 9;25(1):217
Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer.
Zhang L, Zhen Y, Feng L, Li Z, Lu Y, Wang G, Ouyang L
European journal of medicinal chemistry 2023 Nov 5;259:115648
European journal of medicinal chemistry 2023 Nov 5;259:115648
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.
Ma T, Ruan H, Lv L, Wei C, Yu Y, Jia L, Song X, Zhang J, Li Y
Food & function 2023 Nov 13;14(22):9999-10013
Food & function 2023 Nov 13;14(22):9999-10013
Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis.
Liu K, Cao Z, Huang S, Kong F
BMC complementary medicine and therapies 2023 Nov 10;23(1):405
BMC complementary medicine and therapies 2023 Nov 10;23(1):405
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Piao L, Wu D, Rui C, Yang Y, Liu S, Liu J, Jin Z, Zhang H, Feng X, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
Protective effects of Cu/Zn-SOD and Mn-SOD on UVC radiation-induced damage in NIH/3T3 cells and murine skin.
Chen D, Ai X, Li Y, Li Y, Ao Y, Rong J, Li G
Acta histochemica 2023 May;125(4):152030
Acta histochemica 2023 May;125(4):152030
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Liang H, Yan Y, Sun W, Ma X, Su Z, Liu Z, Chen Y, Yu B
International journal of molecular sciences 2023 May 14;24(10)
International journal of molecular sciences 2023 May 14;24(10)
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Yao B, Cai Y, Wang W, Deng J, Zhao L, Han Z, Wan L
Orthopaedic surgery 2023 Mar;15(3):858-867
Orthopaedic surgery 2023 Mar;15(3):858-867
Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis.
Liu W, Zhao X, Wu X
Journal of orthopaedic surgery and research 2023 Mar 8;18(1):177
Journal of orthopaedic surgery and research 2023 Mar 8;18(1):177
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
Pan Y, Liu J, Gao Y, Guo Y, Wang C, Liang Z, Wu M, Qian Y, Li Y, Shen J, Lu C, Ma S
Journal of experimental & clinical cancer research : CR 2023 Mar 29;42(1):75
Journal of experimental & clinical cancer research : CR 2023 Mar 29;42(1):75
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
Ji X, Du W, Che W, Wang L, Zhao L
Molecules (Basel, Switzerland) 2023 Mar 24;28(7)
Molecules (Basel, Switzerland) 2023 Mar 24;28(7)
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases.
Chuang KC, Lai YW, Ko CH, Yen CC, Chen HL, Lan YW, Chen CF, Chen W, Chen CM
Life sciences 2023 Mar 15;317:121411
Life sciences 2023 Mar 15;317:121411
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
Guo Q, Zhang M, Dong Y, Liu K, Wang D, Zheng J
International immunopharmacology 2023 Jun;119:110102
International immunopharmacology 2023 Jun;119:110102
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation.
Cai J, Wang Y, Wang X, Ai Z, Li T, Pu X, Yang X, Yao Y, He J, Cheng SY, Yu T, Liu C, Yue S
Cell & bioscience 2023 Jan 22;13(1):15
Cell & bioscience 2023 Jan 22;13(1):15
Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro.
Jia H, Vashisth MK, Ge Y, Dai Q, He F, Wang X
Biochemical and biophysical research communications 2023 Jan 1;638:103-111
Biochemical and biophysical research communications 2023 Jan 1;638:103-111
Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy.
Lin J, Guo Z, Zheng Z, Hou L, Xu J, Liu Q, Du T, Guo F, Jing X
Life sciences 2023 Jan 1;312:121172
Life sciences 2023 Jan 1;312:121172
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo.
Cai T, Ye H, Jiang H, Lin C, Lou C, Wang W, Yan Z, Xue X, Pan X, Lin J
International immunopharmacology 2023 Feb;115:109683
International immunopharmacology 2023 Feb;115:109683
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Wang X, Guo Z, Lin J, Sun K, Wang G, Hou L, Xu J, Guo J, Zhang X, Guo F, Wei Y
International immunopharmacology 2023 Feb;115:109624
International immunopharmacology 2023 Feb;115:109624
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Pang Y, Zhao L, Ji X, Guo K, Yin X
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Chai Q, Zhang B, Da Y, Wang W, Gao Y, Yao M, Zhu H, Yang X, Zhu Y
Cartilage 2023 Dec;14(4):506-515
Cartilage 2023 Dec;14(4):506-515
FUNDC1/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis.
Fang G, Wen X, Jiang Z, Du X, Liu R, Zhang C, Huang G, Liao W, Zhang Z
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Dec 6;31(12):3594-3612
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Dec 6;31(12):3594-3612
MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression.
Chen J, Liu Z, Sun H, Liu M, Wang J, Zheng C, Cao X
Aging 2023 Dec 13;15(23):14457-14472
Aging 2023 Dec 13;15(23):14457-14472
Bauhinia championii alleviates extracellular matrix degradation in IL-1β induced chondrocytes via miRNA-145-5p/TLR4/NF-κB axis.
Lin J, Huang Y, Lin X, Liu W, Wu X, Qiu H, Wang R
Heliyon 2023 Aug;9(8):e19138
Heliyon 2023 Aug;9(8):e19138
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.
Nee K, Ma D, Nguyen QH, Pein M, Pervolarakis N, Insua-Rodríguez J, Gong Y, Hernandez G, Alshetaiwi H, Williams J, Rauf M, Dave KR, Boyapati K, Hasnain A, Calderon C, Markaryan A, Edwards R, Lin E, Parajuli R, Zhou P, Nie Q, Shalabi S, LaBarge MA, Kessenbrock K
Nature genetics 2023 Apr;55(4):595-606
Nature genetics 2023 Apr;55(4):595-606
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Identification of hub genes and pathways in lung metastatic colorectal cancer.
Dai W, Guo C, Wang Y, Li Y, Xie R, Wu J, Yao B, Xie D, He L, Li Y, Huang H, Wang Y, Liu S
BMC cancer 2023 Apr 6;23(1):323
BMC cancer 2023 Apr 6;23(1):323
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study.
Ding Q, Zhang R, Sheng G, Wang T, Jing S, Ma T, Wang S, Zhao H, Wu H, Li W
Journal of inflammation (London, England) 2023 Apr 13;20(1):14
Journal of inflammation (London, England) 2023 Apr 13;20(1):14
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.
Ma T, Chen H, Ruan H, Lv L, Yu Y, Jia L, Zhao J, Li X, Zang Y, Xu X, Zhang J, Gao L
Frontiers in veterinary science 2022;9:1034623
Frontiers in veterinary science 2022;9:1034623
Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration.
Zheng HL, Xu WN, Chen PB, Jiang LS, Zheng XF, Jiang SD
Oxidative medicine and cellular longevity 2022;2022:9731800
Oxidative medicine and cellular longevity 2022;2022:9731800
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway.
Li S, Shi Y, Zhang S, Li H, Ye Z, Kong J, Hong W, Tu Y, Ren J, Meftah Z, Xie C, Wang X, Zhang X
Oxidative medicine and cellular longevity 2022;2022:2188145
Oxidative medicine and cellular longevity 2022;2022:2188145
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Ma T, Jia L, Zhao J, Lv L, Yu Y, Ruan H, Song X, Chen H, Li X, Zhang J, Gao L
Frontiers in pharmacology 2022;13:1027553
Frontiers in pharmacology 2022;13:1027553
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Jing S, Wan J, Wang T, He Z, Ding Q, Sheng G, Wang S, Zhao H, Zhu Z, Wu H, Li W
Frontiers in bioengineering and biotechnology 2022;10:1071776
Frontiers in bioengineering and biotechnology 2022;10:1071776
CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway.
Cheng T, Wu J, Xu Y, Liu C, Zhang H, Wang M
Journal of bone and mineral metabolism 2022 Sep;40(5):819-828
Journal of bone and mineral metabolism 2022 Sep;40(5):819-828
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Wang W, Jing X, Du T, Ren J, Liu X, Chen F, Shao Y, Sun S, Yang G, Cui X
Free radical biology & medicine 2022 Sep;190:234-246
Free radical biology & medicine 2022 Sep;190:234-246
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Journal of nanobiotechnology 2022 Sep 19;20(1):420
180-W GreenLight laser photoselective vaporization with multiple triamcinolone acetonide injections for the treatment of bladder neck contractures.
Sun X, Jin X, Leng K, Zhao Y, Zhang H
Lasers in medical science 2022 Oct;37(8):3115-3121
Lasers in medical science 2022 Oct;37(8):3115-3121
Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.
Xiong Y, Song X, Kudusi, Zu X, Chen M, He W, Qi L
Functional & integrative genomics 2022 Oct;22(5):937-950
Functional & integrative genomics 2022 Oct;22(5):937-950
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
Belinostat (PXD101) resists UVB irradiation-induced cellular senescence and skin photoaging.
Jia HJ, Ge Y, Xia J, Shi YL, Wang XB
Biochemical and biophysical research communications 2022 Oct 30;627:122-129
Biochemical and biophysical research communications 2022 Oct 30;627:122-129
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Zhao Y, Guo Y, Sun M, Hussion S, Zheng Y, Huang H, Huo X, Zhao Y, Zhang F, Han Y, Ning Q, Xu P, Sun J, Lu S
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Epigenetic Changes within the Annulus Fibrosus by DNA Methylation in Rat Intervertebral Disc Degeneration Model.
Hong JY, Kim H, Jeon WJ, Lee J, Yeo C, Lee YJ, Ha IH
Cells 2022 Nov 10;11(22)
Cells 2022 Nov 10;11(22)
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Li T, Zhai D, Zhang M, Ye R, Kuang X, Shao N, Bi J, Lin Y
Cancer letters 2022 Nov 1;548:215904
Cancer letters 2022 Nov 1;548:215904
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Dai WY, Luo ZP
Cellular signalling 2022 Mar;91:110243
Cellular signalling 2022 Mar;91:110243
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, Zhao L, Liu H, Wang B, Chen S, Shao Z
Experimental & molecular medicine 2022 Mar;54(3):309-323
Experimental & molecular medicine 2022 Mar;54(3):309-323
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Wang J, Xia D, Lin Y, Xu W, Wu Y, Chen J, Chu J, Shen P, Weng S, Wang X, Shen L, Fan S, Shen S
Experimental & molecular medicine 2022 Mar;54(3):285-297
Experimental & molecular medicine 2022 Mar;54(3):285-297
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.
Guo D, Lin C, Lu Y, Guan H, Qi W, Zhang H, Shao Y, Zeng C, Zhang R, Zhang H, Bai X, Cai D
Bone research 2022 Jun 22;10(1):45
Bone research 2022 Jun 22;10(1):45
Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling.
Sun Z, Liu Q, Lv Z, Li J, Xu X, Sun H, Wang M, Sun K, Shi T, Liu Z, Tan G, Yan W, Wu R, Yang YX, Ikegawa S, Jiang Q, Sun Y, Shi D
Acta pharmaceutica Sinica. B 2022 Jul;12(7):3073-3084
Acta pharmaceutica Sinica. B 2022 Jul;12(7):3073-3084
Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway.
Jia N, Ma H, Zhang T, Wang L, Cui J, Zha Y, Ding Y, Wang J
International immunopharmacology 2022 Jul;108:108854
International immunopharmacology 2022 Jul;108:108854
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.
Hu Z, Xiao M, Cai H, Li W, Fang W, Long X
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936
Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints.
Nishi K, Hirano Y, Sato A, Eguchi A, Matsuda K, Toda M, Watanabe T, Iwasaki T, Takahashi N, Hosotani M, Watanabe R, Kato T, Ohtsuka H, Gondaira S, Higuchi H
Veterinary immunology and immunopathology 2022 Feb;244:110364
Veterinary immunology and immunopathology 2022 Feb;244:110364
The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Li R, Guan Z, Bi S, Wang F, He L, Niu X, You Y, Liu Y, Ding Y, Siwko S, Wang N, Zhang Z, Jin Y, Luo J
Cell death & disease 2022 Feb 14;13(2):152
Cell death & disease 2022 Feb 14;13(2):152
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells.
Wang Y, Ouyang Q, Chang X, Yang M, He J, Tian Y, Sheng J
Drug delivery 2022 Dec;29(1):871-881
Drug delivery 2022 Dec;29(1):871-881
Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase.
Koike H, Nishida Y, Shinomura T, Ohkawara B, Ohno K, Zhuo L, Kimata K, Ushida T, Imagama S
International journal of molecular sciences 2022 Apr 7;23(8)
International journal of molecular sciences 2022 Apr 7;23(8)
PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer.
Liu WL, Guan Q, Wen D, Ma B, Xu WB, Hu JQ, Wei WJ, Li DS, Wang Y, Xiang J, Liao T, Ji QH
Frontiers in cell and developmental biology 2021;9:723777
Frontiers in cell and developmental biology 2021;9:723777
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Liu W, Chen Y, Zeng G, Yang S, Yang T, Ma M, Song W
Frontiers in molecular biosciences 2021;8:748360
Frontiers in molecular biosciences 2021;8:748360
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Li BL, Liu X, Gao M, Zhang F, Chen X, He Z, Wang J, Tian W, Chen D, Zhou Z, Liu S
Oxidative medicine and cellular longevity 2021;2021:5608133
Oxidative medicine and cellular longevity 2021;2021:5608133
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
Hu X, Li R, Sun M, Kong Y, Zhu H, Wang F, Wan Q
Journal of inflammation research 2021;14:1403-1414
Journal of inflammation research 2021;14:1403-1414
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Li L, Wei K, Ding Y, Ahati P, Xu H, Fang H, Wang H
Frontiers in immunology 2021;12:666361
Frontiers in immunology 2021;12:666361
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, Wang F, Ma H, Cao L
Frontiers in pharmacology 2021;12:659597
Frontiers in pharmacology 2021;12:659597
Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.
Huang X, Pei W, Ni B, Zhang R, You H
European journal of pharmacology 2021 Sep 5;906:174232
European journal of pharmacology 2021 Sep 5;906:174232
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.
Jing X, Wang Q, Du T, Zhang W, Liu X, Liu Q, Li T, Wang G, Chen F, Cui X
International journal of molecular medicine 2021 Oct;48(4)
International journal of molecular medicine 2021 Oct;48(4)
Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway.
Li Y, Zeng N, Qin Z, Chen Y, Lu Q, Cheng Y, Xia Q, Lu Z, Gu N, Luo D
Nanoscale 2021 Oct 8;13(38):16104-16112
Nanoscale 2021 Oct 8;13(38):16104-16112
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Kong L, Ma Y, Wang Z, Liu N, Ma G, Liu C, Shi R, Du G
International immunopharmacology 2021 May;94:107507
International immunopharmacology 2021 May;94:107507
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Shao Z, Wang B, Shi Y, Xie C, Huang C, Chen B, Zhang H, Zeng G, Liang H, Wu Y, Zhou Y, Tian N, Wu A, Gao W, Wang X, Zhang X
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.
Miao Z, Ding Y, Bi Y, Chen M, Cao X, Wang F
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Jun;54(3):411-419
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Jun;54(3):411-419
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
Jing X, Du T, Li T, Yang X, Wang G, Liu X, Jiang Z, Cui X
Journal of cellular and molecular medicine 2021 Jun;25(12):5671-5680
Journal of cellular and molecular medicine 2021 Jun;25(12):5671-5680
Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling.
Zhu ML, Li JC, Wang L, Zhong X, Zhang YW, Tan RZ, Wang HL, Fan JM, Wang L
Journal of Asian natural products research 2021 Jun;23(6):584-595
Journal of Asian natural products research 2021 Jun;23(6):584-595
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
An impaired healing model of osteochondral defect in papain-induced arthritis.
Meng X, Grad S, Wen C, Lai Y, Alini M, Qin L, Wang X
Journal of orthopaedic translation 2021 Jan;26:101-110
Journal of orthopaedic translation 2021 Jan;26:101-110
GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
Yu X, Jin J, Zheng Y, Zhu H, Xu H, Ma J, Lan Q, Zhuang Z, Chen CC, Li M
Cell death & disease 2021 Feb 19;12(2):203
Cell death & disease 2021 Feb 19;12(2):203
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Lan CN, Cai WJ, Shi J, Yi ZJ
Molecular medicine reports 2021 Dec;24(6)
Molecular medicine reports 2021 Dec;24(6)
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Sang W, Xue S, Jiang Y, Lu H, Zhu L, Wang C, Ma J
Life sciences 2021 Aug 1;278:119528
Life sciences 2021 Aug 1;278:119528
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Zhang Y, Weng Q, Chen J, Li M, Han J
Experimental and therapeutic medicine 2021 Apr;21(4):388
Experimental and therapeutic medicine 2021 Apr;21(4):388
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Ding W, Ge Y, Sun H, Xu J, Gu H, Bian C, Chen H, Jiang L, Yin X
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis.
Jing X, Lin J, Du T, Jiang Z, Li T, Wang G, Liu X, Cui X, Sun K
Frontiers in cell and developmental biology 2020;8:594509
Frontiers in cell and developmental biology 2020;8:594509
Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.
He X, Huang Z, Liu P, Li Q, Wang M, Qiu M, Xiong Z, Yang S
BioMed research international 2020;2020:3126182
BioMed research international 2020;2020:3126182
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Wu Y, Wang Z, Lin Z, Fu X, Zhan J, Yu K
Frontiers in pharmacology 2020;11:682
Frontiers in pharmacology 2020;11:682
Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1β expression in mononuclear cells.
Nishi K, Gondaira S, Okamoto M, Watanabe R, Hirano Y, Fujiki J, Iwano H, Higuchi H
Veterinary immunology and immunopathology 2020 Sep;227:110057
Veterinary immunology and immunopathology 2020 Sep;227:110057
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Shao Z, Pan Z, Lin J, Zhao Q, Wang Y, Ni L, Feng S, Tian N, Wu Y, Sun L, Gao W, Zhou Y, Zhang X, Wang X
Aging 2020 Oct 7;12(19):19254-19272
Aging 2020 Oct 7;12(19):19254-19272
Gut microbiota regulate tumor metastasis via circRNA/miRNA networks.
Zhu Z, Huang J, Li X, Xing J, Chen Q, Liu R, Hua F, Qiu Z, Song Y, Bai C, Mo YY, Zhang Z
Gut microbes 2020 Nov 9;12(1):1788891
Gut microbes 2020 Nov 9;12(1):1788891
lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells.
Zhan S, Wang K, Xiang Q, Song Y, Li S, Liang H, Luo R, Wang B, Liao Z, Zhang Y, Yang C
Journal of cellular physiology 2020 Mar;235(3):2195-2208
Journal of cellular physiology 2020 Mar;235(3):2195-2208
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
Yan Z, Lin Z, Wu Y, Zhan J, Qi W, Lin J, Shen J, Xue X, Pan X
International immunopharmacology 2020 Jul;84:106511
International immunopharmacology 2020 Jul;84:106511
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
Yang R, Chen J, Zhang J, Qin R, Wang R, Qiu Y, Mao Z, Goltzman D, Miao D
Aging cell 2020 Feb;19(2):e13095
Aging cell 2020 Feb;19(2):e13095
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Zhang C, Shao Z, Hu X, Chen Z, Li B, Jiang R, Bsoul N, Chen J, Xu C, Gao W
International immunopharmacology 2020 Dec;89(Pt B):107079
International immunopharmacology 2020 Dec;89(Pt B):107079
Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.
Poole AT, Sitko CA, Le C, Naus CC, Hill BM, Bushnell EAC, Chen VC
Journal of enzyme inhibition and medicinal chemistry 2020 Dec;35(1):672-681
Journal of enzyme inhibition and medicinal chemistry 2020 Dec;35(1):672-681
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Shao Z, Lu J, Zhang C, Zeng G, Chen B, Liang H, Wu A, Zhang X, Wang X
Food & function 2020 Dec 1;11(12):10864-10875
Food & function 2020 Dec 1;11(12):10864-10875
Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL-1β-Treated Rat Chondrocytes via Suppressing MAPK and NF-κB Signaling Pathways.
Ni B, Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X, You H
Inflammation 2020 Aug;43(4):1209-1221
Inflammation 2020 Aug;43(4):1209-1221
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Huang X, You Y, Xi Y, Ni B, Chu X, Zhang R, You H
Inflammation 2020 Apr;43(2):619-628
Inflammation 2020 Apr;43(2):619-628
Tumor-associated macrophages (TAMs) depend on Shp2 for their anti-tumor roles in colorectal cancer.
Wang S, Yao Y, Li H, Zheng G, Lu S, Chen W
American journal of cancer research 2019;9(9):1957-1969
American journal of cancer research 2019;9(9):1957-1969
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
Wang S, Yao Y, Wang X, Zheng G, Ouyang W, Chen W
American journal of cancer research 2019;9(10):2140-2155
American journal of cancer research 2019;9(10):2140-2155
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
Cx43-Associated Secretome and Interactome Reveal Synergistic Mechanisms for Glioma Migration and MMP3 Activation.
Aftab Q, Mesnil M, Ojefua E, Poole A, Noordenbos J, Strale PO, Sitko C, Le C, Stoynov N, Foster LJ, Sin WC, Naus CC, Chen VC
Frontiers in neuroscience 2019;13:143
Frontiers in neuroscience 2019;13:143
Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3.
Jin Y, Li Y, Wang X, Yang Y
Journal of Cancer 2019;10(12):2720-2734
Journal of Cancer 2019;10(12):2720-2734
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, Pan J
Frontiers in pharmacology 2019;10:570
Frontiers in pharmacology 2019;10:570
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Cecen B, Keles D, Oktay G, Kozaci LD
Chemico-biological interactions 2019 Sep 1;310:108730
Chemico-biological interactions 2019 Sep 1;310:108730
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.
Wu Y, Lin Z, Yan Z, Wang Z, Fu X, Yu K
International immunopharmacology 2019 Oct;75:105715
International immunopharmacology 2019 Oct;75:105715
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y
Oncology reports 2019 Oct;42(4):1451-1458
Oncology reports 2019 Oct;42(4):1451-1458
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Li H, Tong X, Xu Y, Wang M, Dai H, Shi T, Sun M, Chen K, Cheng X, Wei Q
Carcinogenesis 2019 Oct 16;40(10):1209-1219
Carcinogenesis 2019 Oct 16;40(10):1209-1219
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
Son KM, Jung HA, Hong JI, Park IY, Kim HA
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Nov;37(11):2411-2419
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Nov;37(11):2411-2419
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats.
Yu H, Zeng R, Lin Y, Li X, Tasneem S, Yang Z, Qiu YX, Li B, Wang YH, Cai X, Wang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 May;58:152876
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 May;58:152876
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
Sun JC, Zheng B, Sun RX, Meng YK, Wang SM, Yang HS, Chen Y, Shi JG, Guo YF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108652
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108652
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
Wang S, Yao Y, Rao C, Zheng G, Chen W
International journal of oncology 2019 Mar;54(3):966-980
International journal of oncology 2019 Mar;54(3):966-980
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M
Bone 2019 Jun;123:129-136
Bone 2019 Jun;123:129-136
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu J, Zhu M, Zhou M, Yang M, Mu M, Chen W, Zhou B, Zhang J, Tang K
Cell proliferation 2019 Jul;52(4):e12650
Cell proliferation 2019 Jul;52(4):e12650
Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype.
Simão M, Gavaia PJ, Camacho A, Porto G, Pinto IJ, Ea HK, Cancela ML
BioFactors (Oxford, England) 2019 Jul;45(4):583-597
BioFactors (Oxford, England) 2019 Jul;45(4):583-597
Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis.
Yao Y, Rao C, Zheng G, Wang S
Oncology reports 2019 Jul;42(1):131-141
Oncology reports 2019 Jul;42(1):131-141
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Li X, Huang Y, Guo S, Xie M, Bin X, Shi M, Chen A, Chen S, Wu F, Hu Q, Zhou S
Oncology letters 2019 Jul;18(1):609-616
Oncology letters 2019 Jul;18(1):609-616
Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.
Ohnishi T, Yamada K, Iwasaki K, Tsujimoto T, Higashi H, Kimura T, Iwasaki N, Sudo H
Scientific reports 2019 Dec 18;9(1):19324
Scientific reports 2019 Dec 18;9(1):19324
A mechanism of regucalcin knock-down in the promotion of proliferation and movement of human cervical cancer HeLa cells.
Li X, Huang Y, Wang P, Song W, Yao Q, Hu Q, Zhou S
Translational cancer research 2019 Apr;8(2):402-409
Translational cancer research 2019 Apr;8(2):402-409
Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway.
Wang Y, Lv Y, Liu TS, Yan WD, Chen LY, Li ZH, Piao YS, An RB, Lin ZH, Ren XS
Life sciences 2019 Apr 15;223:110-119
Life sciences 2019 Apr 15;223:110-119
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Katsara O, Kolupaeva V
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Oct;36(10):2728-2735
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Oct;36(10):2728-2735
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Ding QH, Ye CY, Chen EM, Zhang W, Wang XH
International immunopharmacology 2018 Aug;61:222-230
International immunopharmacology 2018 Aug;61:222-230
Tumor cell density regulates matrix metalloproteinases for enhanced migration.
Jayatilaka H, Umanzor FG, Shah V, Meirson T, Russo G, Starich B, Tyle P, Lee JSH, Khatau S, Gil-Henn H, Wirtz D
Oncotarget 2018 Aug 24;9(66):32556-32569
Oncotarget 2018 Aug 24;9(66):32556-32569
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Zeng L, Xiao CZ, Deng ZT, Li RH
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8985623
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8985623
Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression.
Shen H, Wang H, Wang L, Wang L, Zhu M, Ming Y, Zhao S, Fan J, Lai EY
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8231936
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8231936
Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.
Wang L, Hu L, Zhou X, Xiong Z, Zhang C, Shehada HMA, Hu B, Song J, Chen L
Scientific reports 2017 Oct 17;7(1):13321
Scientific reports 2017 Oct 17;7(1):13321
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S
Oncotarget 2017 Oct 10;8(47):81880-81891
Oncotarget 2017 Oct 10;8(47):81880-81891
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Zeng L, Rong XF, Li RH, Wu XY
Molecular medicine reports 2017 May;15(5):2853-2858
Molecular medicine reports 2017 May;15(5):2853-2858
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells.
Gao Y, Zhang Z, Li K, Gong L, Yang Q, Huang X, Hong C, Ding M, Yang H
Cell death & disease 2017 Jul 13;8(7):e2924
Cell death & disease 2017 Jul 13;8(7):e2924
Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions.
Nakamura DS, Hollander JM, Uchimura T, Nielsen HC, Zeng L
BMC musculoskeletal disorders 2017 Jan 25;18(1):39
BMC musculoskeletal disorders 2017 Jan 25;18(1):39
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q
Scientific reports 2017 Feb 22;7:43245
Scientific reports 2017 Feb 22;7:43245
Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.
Wang S, Zhang C, Zhang Z, Qian W, Sun Y, Ji B, Zhang Y, Zhu C, Ji D, Wang Q, Sun Y
Cancer medicine 2017 Aug;6(8):1976-1987
Cancer medicine 2017 Aug;6(8):1976-1987
18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration.
Wang S, Shen Y, Qiu R, Chen Z, Chen Z, Chen W
International journal of oncology 2017 Aug;51(2):615-624
International journal of oncology 2017 Aug;51(2):615-624
Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease.
Qu H, Li J, Wu LD, Chen WP
Molecular medicine reports 2016 Sep;14(3):2423-30
Molecular medicine reports 2016 Sep;14(3):2423-30
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Hu B, Song Z, Liu H, Qiao L, Zhao Y, Wang M, Song W, Zhang D, Jin X, Zhang H
Lasers in medical science 2016 Nov;31(8):1573-1581
Lasers in medical science 2016 Nov;31(8):1573-1581
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
Camacho A, Simão M, Ea HK, Cohen-Solal M, Richette P, Branco J, Cancela ML
Osteoarthritis and cartilage 2016 Mar;24(3):494-502
Osteoarthritis and cartilage 2016 Mar;24(3):494-502
DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.
Tan C, Qiao F, Wei P, Chi Y, Wang W, Ni S, Wang Q, Chen T, Sheng W, Du X, Wang L
Molecular carcinogenesis 2016 Apr;55(4):397-408
Molecular carcinogenesis 2016 Apr;55(4):397-408
Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma.
Mehner C, Miller E, Nassar A, Bamlet WR, Radisky ES, Radisky DC
Genes & cancer 2015 Nov;6(11-12):480-9
Genes & cancer 2015 Nov;6(11-12):480-9
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Yang SD, Yang DL, Sun YP, Wang BL, Ma L, Feng SQ, Ding WY
Apoptosis : an international journal on programmed cell death 2015 Mar;20(3):348-57
Apoptosis : an international journal on programmed cell death 2015 Mar;20(3):348-57
BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs.
Liu Z, Wei P, Yang Y, Cui W, Cao B, Tan C, Yu B, Bi R, Xia K, Chen W, Wang Y, Zhang Y, Du X, Zhou X
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Apr 1;21(7):1752-63
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Apr 1;21(7):1752-63
Matrix metalloproteinase 3 promotes cellular anti-dengue virus response via interaction with transcription factor NFκB in cell nucleus.
Zuo X, Pan W, Feng T, Shi X, Dai J
PloS one 2014;9(1):e84748
PloS one 2014;9(1):e84748
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.
Mehner C, Miller E, Khauv D, Nassar A, Oberg AL, Bamlet WR, Zhang L, Waldmann J, Radisky ES, Crawford HC, Radisky DC
Molecular cancer research : MCR 2014 Oct;12(10):1430-9
Molecular cancer research : MCR 2014 Oct;12(10):1430-9
Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC).
Ma F, Li H, Wang H, Shi X, Fan Y, Ding X, Lin C, Zhan Q, Qian H, Xu B
Cancer letters 2014 Oct 28;353(2):153-9
Cancer letters 2014 Oct 28;353(2):153-9
Rho GDP dissociation inhibitor beta promotes cell proliferation and invasion by modulating the AKT pathway in hepatocellular carcinoma.
Fang Y, Yi J, Lizhi L, Qiucheng C
DNA and cell biology 2014 Nov;33(11):781-6
DNA and cell biology 2014 Nov;33(11):781-6
Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo.
Li J, Zhou XD, Yang KH, Fan TD, Chen WP, Jiang LF, Bao JP, Wu LD, Xiong Y
International immunopharmacology 2014 Nov;23(1):85-91
International immunopharmacology 2014 Nov;23(1):85-91
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
Wu DQ, Zhong HM, Ding QH, Ba L
BMC complementary and alternative medicine 2014 Nov 15;14:444
BMC complementary and alternative medicine 2014 Nov 15;14:444
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y
Arthritis and rheumatism 2013 May;65(5):1160-70
Arthritis and rheumatism 2013 May;65(5):1160-70
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Ding QH, Cheng Y, Chen WP, Zhong HM, Wang XH
European journal of pharmacology 2013 May 15;708(1-3):1-7
European journal of pharmacology 2013 May 15;708(1-3):1-7
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Ding Q, Zhong H, Qi Y, Cheng Y, Li W, Yan S, Wang X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jan;62(1):17-25
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jan;62(1):17-25
Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes.
Fong G, Backman LJ, Hart DA, Danielson P, McCormack B, Scott A
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Jan;31(1):91-8
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Jan;31(1):91-8
CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2.
Zhang M, Liu Y, Feng H, Bian X, Zhao W, Yang Z, Gu B, Li Z, Liu Y
The American journal of pathology 2013 Feb;182(2):565-76
The American journal of pathology 2013 Feb;182(2):565-76
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 17873-1-AP(MMP3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 17873-1-AP(MMP3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MMP3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MMP3. This antibody recognizes human,mouse,rat, zebrafish antigen. The MMP3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
