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- Antibody Data
- Antigen structure
- References [23]
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- Validations
- Western blot [1]
- Immunocytochemistry [2]
- Immunohistochemistry [2]
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- Product number
- 19492-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19492-1-AP, RRID:AB_10638445
- Product name
- ADCY3 antibody
- Antibody type
- Polyclonal
- Description
- ADCY3 antibody (Cat. #19492-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment.
5-HT6R-ATR-primary cilia network supports morphine-related memory extinction in the medial prefrontal cortex.
In-depth analysis of obesity-associated changes in adipose tissue-derived mesenchymal stromal/stem cells and primary cilia function.
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
Regulation of perinatal estrogen levels on primordial follicle formation and activation in mouse.
Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length.
KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling.
Cerebral furin deficiency causes hydrocephalus in mice.
Liraglutide improved the reproductive function of obese mice by upregulating the testicular AC3/cAMP/PKA pathway.
Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats.
Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.
Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.
Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring.
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder.
Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity.
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
A Cell-Based Assay Optimized for High-Content Cilia Imaging with Primary Rat Hippocampal Neurons.
Aromatherapy: Activating olfactory calcium-sensing receptors impairs renal hemodynamics via sympathetic nerve-mediated vasoconstriction.
Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease.
Jin L, Wei L, Hua J, Zhang R, Chen J, He J, Yang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment.
Zhang J, Chen Z
International journal of biological macromolecules 2026 Apr;353:150951
International journal of biological macromolecules 2026 Apr;353:150951
5-HT6R-ATR-primary cilia network supports morphine-related memory extinction in the medial prefrontal cortex.
Liu J, Yang X, Gao F, Yang J, Yang Z, Liao Q, Shen M, Yu D, Zhang Y, Yan C
iScience 2025 Sep 19;28(9):113208
iScience 2025 Sep 19;28(9):113208
In-depth analysis of obesity-associated changes in adipose tissue-derived mesenchymal stromal/stem cells and primary cilia function.
Kreis NN, Friemel A, Ritter A, Hentrich AE, Siebelitz E, Louwen F, Yuan J
Communications biology 2025 Oct 13;8(1):1462
Communications biology 2025 Oct 13;8(1):1462
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
Shi XK, Sheng YW, Cao DY, Shi N, Zhang GL, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70688
Regulation of perinatal estrogen levels on primordial follicle formation and activation in mouse.
Xu R, Yin L, Zhang Y, Niu Y, Lu S, Tang Y, Peng S, Pan M, Ma B
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E772-E786
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E772-E786
Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.
Liu Y, Dong Y, Jiang Y, Han S, Liu X, Xu X, Zhu A, Zhao Z, Gao Y, Zou Y, Zhang C, Bian Y, Zhang Y, Liu J, Zhao S, Zhao H, Chen ZJ
Cell metabolism 2025 Apr 1;37(4):920-935.e6
Cell metabolism 2025 Apr 1;37(4):920-935.e6
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Mao J, Chen Y, Zong Q, Liu C, Xie J, Wang Y, Fisher D, Hien NTT, Pronyuk K, Musabaev E, Li Y, Zhao L, Dang Y
Frontiers in immunology 2024;15:1364161
Frontiers in immunology 2024;15:1364161
Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length.
Ansari SS, Dillard ME, Zhang Y, Austria MA, Boatwright N, Shelton EL, Stewart DP, Johnson A, Wang CE, Young BM, Rankovic Z, Hansen BS, Pruett-Miller SM, Carisey AF, Schuetz JD, Robinson CG, Ogden SK
The Journal of cell biology 2024 Sep 2;223(9)
The Journal of cell biology 2024 Sep 2;223(9)
KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling.
Liao Y, Muntean BS
Proceedings of the National Academy of Sciences of the United States of America 2024 Oct 22;121(43):e2406686121
Proceedings of the National Academy of Sciences of the United States of America 2024 Oct 22;121(43):e2406686121
Cerebral furin deficiency causes hydrocephalus in mice.
Xie S, Xie X, Tang J, Luo B, Chen J, Wen Q, Zhou J, Chen G
Genes & diseases 2024 May;11(3):101009
Genes & diseases 2024 May;11(3):101009
Liraglutide improved the reproductive function of obese mice by upregulating the testicular AC3/cAMP/PKA pathway.
Qi R, Liang Y, Yu J, Chen B, Jiang J, Wu X, Lu W, Li Z
Reproductive biology and endocrinology : RB&E 2024 Mar 20;22(1):31
Reproductive biology and endocrinology : RB&E 2024 Mar 20;22(1):31
Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats.
Li Y, Liu P, Yao Y, Wang W, Jia H, Bai Y, Yuan Z, Yang Z
Molecular therapy. Nucleic acids 2024 Jun 11;35(2):102163
Molecular therapy. Nucleic acids 2024 Jun 11;35(2):102163
Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.
Luo S, Li Y, Li S, Jiang R, Deng F, Liu G, Zhang J
Frontiers in physiology 2022;13:856427
Frontiers in physiology 2022;13:856427
Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.
Okamoto Y, Aung NY, Tanaka M, Takeda Y, Takagi D, Igarashi W, Ishii K, Yamakawa M, Ono K
Biomolecules 2022 May 20;12(5)
Biomolecules 2022 May 20;12(5)
Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring.
Long HP, Liu J, Xu PS, Xu KP, Li J, Tan GS
Phytochemistry 2022 Mar;195:113073
Phytochemistry 2022 Mar;195:113073
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder.
Di Nardo A, Rühmkorf A, Award P, Brennecke A, Fagiolini M, Sahin M
Neuroscience research 2022 Mar;176:73-78
Neuroscience research 2022 Mar;176:73-78
Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity.
Ran J, Zhang Y, Zhang S, Li H, Zhang L, Li Q, Qin J, Li D, Sun L, Xie S, Zhang X, Liu L, Liu M, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jul;9(21):e2105365
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jul;9(21):e2105365
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Gailey CD, Wang EJ, Jin L, Ahmadi S, Brautigan DL, Li X, Xu W, Scott MM, Fu Z
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Di Nardo A, Lenoël I, Winden KD, Rühmkorf A, Modi ME, Barrett L, Ercan-Herbst E, Venugopal P, Behne R, Lopes CAM, Kleiman RJ, Bettencourt-Dias M, Sahin M
Cell reports 2020 Jun 23;31(12):107780
Cell reports 2020 Jun 23;31(12):107780
A Cell-Based Assay Optimized for High-Content Cilia Imaging with Primary Rat Hippocampal Neurons.
Di Nardo A, Vasquez S, Sahin M
STAR protocols 2020 Dec 18;1(3):100189
STAR protocols 2020 Dec 18;1(3):100189
Aromatherapy: Activating olfactory calcium-sensing receptors impairs renal hemodynamics via sympathetic nerve-mediated vasoconstriction.
Lee SP, Wu WY, Hsiao JK, Zhou JH, Chang HH, Chien CT
Acta physiologica (Oxford, England) 2019 Jan;225(1):e13157
Acta physiologica (Oxford, England) 2019 Jan;225(1):e13157
Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease.
Canterini S, Dragotto J, Dardis A, Zampieri S, De Stefano ME, Mangia F, Erickson RP, Fiorenza MT
Human molecular genetics 2017 Jun 15;26(12):2277-2289
Human molecular genetics 2017 Jun 15;26(12):2277-2289
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 19492-1-AP(ADCY3 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using ADCY3 antibody 19492-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ADCY3 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ADCY3. This antibody recognizes human,mouse,rat antigen. The ADCY3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 19492-1-AP(ADCY3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 19492-1-AP(ADCY3 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
