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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
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- Product number
- PAB11251 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB11251, RRID:AB_1711189
- Product name
- PRKCB polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of PRKCB.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references PKCĪ± suppresses osteoblastic differentiation.
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells.
Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.
Nakura A, Higuchi C, Yoshida K, Yoshikawa H
Bone 2011 Mar 1;48(3):476-84
Bone 2011 Mar 1;48(3):476-84
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, Banks C, Capen A, Goode R, Lewis JE, Sams L, Huss KL, Campbell RM, Iversen PW, Neubauer BL, Brown TJ, Musib L, Geeganage S, Thornton D
Cancer research 2005 Aug 15;65(16):7462-9
Cancer research 2005 Aug 15;65(16):7462-9
Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells.
Koivunen J, Aaltonen V, Koskela S, Lehenkari P, Laato M, Peltonen J
Cancer research 2004 Aug 15;64(16):5693-701
Cancer research 2004 Aug 15;64(16):5693-701
Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.
Zhang J, Wang L, Petrin J, Bishop WR, Bond RW
Proceedings of the National Academy of Sciences of the United States of America 1993 Jul 1;90(13):6130-4
Proceedings of the National Academy of Sciences of the United States of America 1993 Jul 1;90(13):6130-4
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Supportive validation
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- Abnova Corporation (provider)
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- Experimental details
- Western blot using PRKCB polyclonal antibody (Cat # PAB11251) shows detection of PRKCB in ~25 ug of U251 whole cell lysate (glioma derived).The arrowhead corresponds to 76 kDa PRKCB.The primary antibody at a 1:1,000 dilution.Personal Communication, Howard Fine and Svetlana Kotliarova, CCR-NCI, Bethesda, MD.
