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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Product number
- ABIN362149 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN362149, RRID:AB_10952611
- Product name
- anti-Janus Kinase 2 (JAK2) (pTyr1007) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr1007 (K-E-Y (p) -Y-K) derived from Human JAK2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr1007
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.
Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.
James C, Ugo V, Le Couédic JP, Staerk J, Delhommeau F, Lacout C, Garçon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W
Nature 2005 Apr 28;434(7037):1144-8
Nature 2005 Apr 28;434(7037):1144-8
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.
Argetsinger LS, Kouadio JL, Steen H, Stensballe A, Jensen ON, Carter-Su C
Molecular and cellular biology 2004 Jun;24(11):4955-67
Molecular and cellular biology 2004 Jun;24(11):4955-67
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.
Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O
Molecular and cellular biology 2002 May;22(10):3316-26
Molecular and cellular biology 2002 May;22(10):3316-26
Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.
Xie S, Wang Y, Liu J, Sun T, Wilson MB, Smithgall TE, Arlinghaus RB
Oncogene 2001 Sep 27;20(43):6188-95
Oncogene 2001 Sep 27;20(43):6188-95
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