517302

antibody from BioLegend

Targeting: IL18 IGIF, IL-18, IL-1g, IL1F4

Western blot (Data presented on provider website)

Antibody Data

Product number

517302

Provider

BioLegend

Proper citation

BioLegend Cat#517302, RRID:AB_10680612

Product name

Purified anti-human IL-18

Antibody type

Monoclonal

Antigen

Recombinant protein

Description

IL-18, initially described as IFN-g inducing factor (IGIF), is a pro-inflammatory cytokine. It is an 18-kD cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12.  IL-18 is synthesized as a precursor 24-kD molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon.  The cytokine IL-18 possesses pleiotropic biological properties such as activation of NF-kb, Fas ligand expression, induction of both CC and CXC chemokines, enhancement of the production of IFN-g and GM-CSF, and induction of CD4+ cytolytic T cell response. Its role in neurodegeneartion disease has also been reported.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgM

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

Upon receipt, store undiluted at 4°C.