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- References [13]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55245-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55245-1-AP, RRID:AB_10951108
- Product name
- HCN2 antibody
- Antibody type
- Polyclonal
- Description
- HCN2 antibody (Cat. #55245-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents.
Restoration of mitochondrial function alleviates trigeminal neuropathic pain in mice.
HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer's disease.
CDK5-Induced HCN2 Channel Dysfunction in the Prelimbic Cortex Drives Allodynia and Anxiety-Like Behaviors in Neuropathic Pain.
Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle.
HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.
HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats.
Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus.
Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia.
HCN2 contributes to oxaliplatin-induced neuropathic pain by inducing spinal long-term potentiation via activation of NMDA receptor-mediated CaMKII signaling.
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co-cultured with atrial myocytes.
Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
Liu XA, Aguirre CA, Yang Q, Ren J, Wang L, Ju F, Guo H, Wang J, Liu L, Li Z, He J, Xu Z, Shi C, Cintron-Colon R, Michel T, Wood M, Margetts AV, Pollock TA, Vilca SJ, Tuesta LM, Di Angelantonio S, Basilico B, De Stefano ME, Xia J, Wei P, Li S, Yang X, Wang L, Delorme-Walker VD, Marcondes MCG, Parsons L, Conti B, Chen Z
Molecular psychiatry 2026 Feb;31(2):622-634
Molecular psychiatry 2026 Feb;31(2):622-634
Restoration of mitochondrial function alleviates trigeminal neuropathic pain in mice.
Yang J, Xie S, Guo J, Zhou Y, Yang Y, Sun Z, Cai P, Zhang C, Jiang S, Cao X, Fan Y, Chen X, Li X, Zhang Y
Free radical biology & medicine 2025 Jan;226:185-198
Free radical biology & medicine 2025 Jan;226:185-198
HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer's disease.
Zhang X, Zhang Y, Zhang T, Wang J, Liu C, Shang Q, Wei X, Zhu H, Shen H, Sun B
Alzheimer's research & therapy 2025 Feb 27;17(1):55
Alzheimer's research & therapy 2025 Feb 27;17(1):55
CDK5-Induced HCN2 Channel Dysfunction in the Prelimbic Cortex Drives Allodynia and Anxiety-Like Behaviors in Neuropathic Pain.
Chen L, Cao S, Liu YZ, Yang QF, Yang JY, Zhang DY, Xie GG, Yin XS, Zhang Y, Wang Y
Neuroscience bulletin 2025 Dec;41(12):2254-2271
Neuroscience bulletin 2025 Dec;41(12):2254-2271
Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle.
Lamia SN, Davis CS, Macpherson PCD, Willingham TB, Zhang Y, Liu C, Iannucci L, Ganji E, Harden D, Bhattacharya I, Abraham AC, Brooks SV, Glancy B, Killian ML
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 30;38(22):e70185
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 30;38(22):e70185
HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.
Cao XZ, Zhu MY, Xu G, Li F, Yan Y, Zhang JJ, Wang J, Zeng F, Bao Y, Zhang XX, Liu T, Zhang DY
CNS neuroscience & therapeutics 2024 Jul;30(7):e14831
CNS neuroscience & therapeutics 2024 Jul;30(7):e14831
HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats.
Wang X, Gan S, Zhang Z, Zhu P, Li CH, Luo F
Molecular neurobiology 2023 May;60(5):2553-2571
Molecular neurobiology 2023 May;60(5):2553-2571
Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus.
Yan Y, Zhu M, Cao X, Xu G, Shen W, Li F, Zhang J, Luo L, Zhang X, Zhang D, Liu T
Neuroscience bulletin 2023 May;39(5):774-792
Neuroscience bulletin 2023 May;39(5):774-792
Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia.
Sciamanna G, Ponterio G, Vanni V, Laricchiuta D, Martella G, Bonsi P, Meringolo M, Tassone A, Mercuri NB, Pisani A
Cell reports 2020 May 19;31(7):107644
Cell reports 2020 May 19;31(7):107644
HCN2 contributes to oxaliplatin-induced neuropathic pain by inducing spinal long-term potentiation via activation of NMDA receptor-mediated CaMKII signaling.
Liu X, Ji Q, Liu F, Jin L, Tan Y, Zhang L, Tang J
Brain research bulletin 2020 Jun;159:61-66
Brain research bulletin 2020 Jun;159:61-66
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Liu X, Zhang L, Jin L, Tan Y, Li W, Tang J
Molecular pain 2018 Jan-Dec;14:1744806918778490
Molecular pain 2018 Jan-Dec;14:1744806918778490
Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co-cultured with atrial myocytes.
Ding C, Yang C, Cao Q, Zhu X, Zhang J, Zhang W, Wang Y, Li L
Experimental and therapeutic medicine 2017 Sep;14(3):2108-2116
Experimental and therapeutic medicine 2017 Sep;14(3):2108-2116
Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
Zhang D, Wu B, Wang P, Wang Y, Lu P, Nechiporuk T, Floss T, Greally JM, Zheng D, Zhou B
Nucleic acids research 2017 Apr 7;45(6):3102-3115
Nucleic acids research 2017 Apr 7;45(6):3102-3115
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 55245-1-AP(HCN2 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55245-1-AP(HCN2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HCN2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human HCN2. This antibody recognizes human, mouse, rat antigen. The HCN2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
