Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- 16174-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16174-1-AP, RRID:AB_2248702
- Product name
- Icam-1 antibody
- Antibody type
- Polyclonal
- Description
- Icam-1 antibody (Cat. #16174-1-AP) is a rabbit polyclonal antibody that shows reactivity with mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Luteolin prevents hyperoxaluria-induced renal injury by inhibiting crystal deposition and renal inflammation.
Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.
Mechanisms of Luoshi Neiyi prescription (LSNYP) in endometriosis: a network pharmacology and experimental study.
Simvastatin Ameliorates Lipid Metabolism-Mediated Endothelial Inflammation and Tight Junction Impairment in Chronic Cerebral Hypoperfusion.
Dual Effects of Sodium Houttuyfonate Against Acute Rhinosinusitis: Antibacterial Action and Epithelial Barrier Repair Through the p38 MAPK/ERK Pathway.
Long non-coding RNA NAV2-AS2 protects against atherosclerosis by regulating EndMT through sense-antisense hybrid formation with NAV2 mRNA.
HIF-1α-mediated inhibition of the sFlt-1/sENG/TNF-α pathway promotes angiogenesis to ameliorate pre-eclampsia.
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.
Protective efficacy and mechanism of gypenosides against diabetic cataracts via the ferroptosis pathway: A study based on network pharmacology.
Exosomes derived from baicalin‑pretreated mesenchymal stem cells mitigate atherosclerosis by regulating the SIRT1/NF‑κB signaling pathway.
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis.
Multifunctional nanoparticles for immune regulation and oxidative stress alleviation in myocarditis.
Dendrobium officinale-derived nanovesicles: a natural therapy for comprehensive regulation of angiogenesis, inflammation, and tissue repair to enhance skin wound healing.
MSCs engineered with secreted Klotho alleviate blood-brain barrier disruption and reduce neuroinflammation more effectively than MSCs in experimental autoimmune encephalomyelitis.
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
Impact of intercellular adhesion molecule 1-positive dental pulp stem cells in deep caries progression.
A Macrophage Membrane-Functionalized, Reactive Oxygen Species-Activatable Nanoprodrug to Alleviate Inflammation and Improve the Lipid Metabolism for Atherosclerosis Management.
Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the α7nAChR/SIRT1 axis.
Silk fibroin promotes H3K9me3 expression and chromatin reorganization to regulate endothelial cell proliferation.
Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy.
Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coli.
Astrocyte-Derived Extracellular Vesicular miR-143-3p Dampens Autophagic Degradation of Endothelial Adhesion Molecules and Promotes Neutrophil Transendothelial Migration after Acute Brain Injury.
FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway.
Cardioprotective effects of polydatin against myocardial injury in HFD/stz and high glucose-induced diabetes via a Caveolin 1-dependent mechanism.
Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease.
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.
The role of 14-3-3 in the progression of vascular inflammation induced by lipopolysaccharide.
CTNNAL1 enhances glucocorticoid sensitivity in HDM-induced asthma mouse model through deactivating hsp90 signaling pathway.
Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity.
Hyperforin regulates renal fibrosis via targeting the PI3K-AKT/ICAM1 axis.
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
SARS-CoV-2 productively infects human brain microvascular endothelial cells.
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus.
LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors.
ICAM-1 Targeted Drug Combination Nanoparticles Enhanced Gemcitabine-Paclitaxel Exposure and Breast Cancer Suppression in Mouse Models.
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis.
Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.
Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain.
Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.
The Selective RNA Polymerase I Inhibitor CX-5461 Mitigates Neointimal Remodeling in a Modified Model of Rat Aortic Transplantation.
Niaspan inhibits diabetic retinopathy‑induced vascular inflammation by downregulating the tumor necrosis factor‑α pathway.
Jin Z, Zhu S, Wang C, Wang T, Liu J, Wu Y
The international journal of biochemistry & cell biology 2026 May;194:106909
The international journal of biochemistry & cell biology 2026 May;194:106909
Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.
Zhao X, Duan H, Dou S, Li X, Lin Y, Zhao C, Li D, Zhou L, Li Z, Zhou Q
Investigative ophthalmology & visual science 2026 Jan 5;67(1):53
Investigative ophthalmology & visual science 2026 Jan 5;67(1):53
Mechanisms of Luoshi Neiyi prescription (LSNYP) in endometriosis: a network pharmacology and experimental study.
Wu L, Su R, Jia J, Kuang Z, Zeng C, Pei F
Hereditas 2026 Jan 19;163(1):24
Hereditas 2026 Jan 19;163(1):24
Simvastatin Ameliorates Lipid Metabolism-Mediated Endothelial Inflammation and Tight Junction Impairment in Chronic Cerebral Hypoperfusion.
Sun R, Li W, Ji X, Hu W, Zhao Y, Lu Y, Shang J, Hao X, Zhang J
Neuromolecular medicine 2026 Feb 6;28(1):9
Neuromolecular medicine 2026 Feb 6;28(1):9
Dual Effects of Sodium Houttuyfonate Against Acute Rhinosinusitis: Antibacterial Action and Epithelial Barrier Repair Through the p38 MAPK/ERK Pathway.
Fang Y, Zhou H, Li W, Bai L, Sun X, He K, Xue S, Wu Y
Journal of inflammation research 2025;18:13433-13452
Journal of inflammation research 2025;18:13433-13452
Long non-coding RNA NAV2-AS2 protects against atherosclerosis by regulating EndMT through sense-antisense hybrid formation with NAV2 mRNA.
Liu G, Zhu L, Cai H, Gao H, Dai W, Chen X, Yan M, Rong R, Zhang J, Zhao X, Wang M, Zhang Z, Yuan T, Kong X, Yan Z, Xia F, Zhang Y, Qin W
International journal of biological macromolecules 2025 Sep;321(Pt 1):146076
International journal of biological macromolecules 2025 Sep;321(Pt 1):146076
HIF-1α-mediated inhibition of the sFlt-1/sENG/TNF-α pathway promotes angiogenesis to ameliorate pre-eclampsia.
Liu J, Zhao M, Zhang S, Shi Y
Journal of molecular histology 2025 Sep 3;56(5):290
Journal of molecular histology 2025 Sep 3;56(5):290
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.
Wei J, Mao R, Chen Y, Si K, Li Y, Li J, Zhu W
Cell death & disease 2025 Nov 17;16(1):832
Cell death & disease 2025 Nov 17;16(1):832
Protective efficacy and mechanism of gypenosides against diabetic cataracts via the ferroptosis pathway: A study based on network pharmacology.
Pei A, Ma Y, Gao M, Zhao Q
European journal of pharmacology 2025 Nov 15;1007:178175
European journal of pharmacology 2025 Nov 15;1007:178175
Exosomes derived from baicalin‑pretreated mesenchymal stem cells mitigate atherosclerosis by regulating the SIRT1/NF‑κB signaling pathway.
Yang X, Wu W, Huang W, Fang J, Chen Y, Chen X, Lin X, He Y
Molecular medicine reports 2025 May;31(5)
Molecular medicine reports 2025 May;31(5)
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis.
Yin B, Qian B, Yu H, Ke S, Li Z, Hua Y, Lu S, Wang C, Li M, Guo S, Li Z, Zhou Y, Meng Z, Li X, Xu Y, Feng Z, Bai M, Fu Y, Tang W, Hong S, Ma Y
Nature communications 2025 May 22;16(1):4779
Nature communications 2025 May 22;16(1):4779
Multifunctional nanoparticles for immune regulation and oxidative stress alleviation in myocarditis.
Ye Z, Zhu M, Li S, Zhang F, Ran Y, Liu C, Xu X, Liu S, Xie X, Wang Y, Yao L
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113607
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113607
Dendrobium officinale-derived nanovesicles: a natural therapy for comprehensive regulation of angiogenesis, inflammation, and tissue repair to enhance skin wound healing.
Tu J, Xu L, Guo Y, Zhang M, Gan M, Bao X, Yang R, Liu H, Lin F
Bioresources and bioprocessing 2025 Jul 12;12(1):74
Bioresources and bioprocessing 2025 Jul 12;12(1):74
MSCs engineered with secreted Klotho alleviate blood-brain barrier disruption and reduce neuroinflammation more effectively than MSCs in experimental autoimmune encephalomyelitis.
Maleki N, Rezapour Kalkhorann M, Emami Aleagha MSS, Emami A, Allameh A
Stem cell research & therapy 2025 Jul 1;16(1):346
Stem cell research & therapy 2025 Jul 1;16(1):346
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
Wang C, Cheng H, Dong X, Zhan Y, Liu Y, Wu N, Tang R, He H, Cao Y, Yang L, Ren J, Li X, Li P
Journal of nanobiotechnology 2025 Feb 12;23(1):104
Journal of nanobiotechnology 2025 Feb 12;23(1):104
Impact of intercellular adhesion molecule 1-positive dental pulp stem cells in deep caries progression.
Zhang Y, Zhang Y, Chen Y, Wu W, Sun J, Zhang X, Zhang J, Chen Z
International endodontic journal 2025 Aug;58(8):1184-1196
International endodontic journal 2025 Aug;58(8):1184-1196
A Macrophage Membrane-Functionalized, Reactive Oxygen Species-Activatable Nanoprodrug to Alleviate Inflammation and Improve the Lipid Metabolism for Atherosclerosis Management.
Qu K, Zhong Y, Zhu L, Mou N, Cao Y, Liu J, Wu S, Yan M, Yan F, Li J, Zhang C, Wu G, Zhang K, Qin X, Wu W
Advanced healthcare materials 2024 Oct;13(26):e2401113
Advanced healthcare materials 2024 Oct;13(26):e2401113
Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the α7nAChR/SIRT1 axis.
Ye A, Li L, Chen H, Tao P, Lou S
Placenta 2024 Mar 6;147:42-51
Placenta 2024 Mar 6;147:42-51
Silk fibroin promotes H3K9me3 expression and chromatin reorganization to regulate endothelial cell proliferation.
Gao K, Xie Y, Xu F, Peng Q, Fu L, Wang G, Qiu J
APL bioengineering 2024 Jun;8(2):026115
APL bioengineering 2024 Jun;8(2):026115
Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy.
Nakashima Y, Tanabe K, Mifune T, Nakadoi T, Hayashi H, Nakagami H, Sato Y, Wada J
American journal of physiology. Renal physiology 2024 Jun 1;326(6):F1054-F1065
American journal of physiology. Renal physiology 2024 Jun 1;326(6):F1054-F1065
Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coli.
Yang R, Wang X, Liu H, Chen J, Tan C, Chen H, Wang X
Cell communication and signaling : CCS 2024 Jan 17;22(1):44
Cell communication and signaling : CCS 2024 Jan 17;22(1):44
Astrocyte-Derived Extracellular Vesicular miR-143-3p Dampens Autophagic Degradation of Endothelial Adhesion Molecules and Promotes Neutrophil Transendothelial Migration after Acute Brain Injury.
Wu X, Liu H, Hu Q, Wang J, Zhang S, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Wu Y, Luo J, Wang T, Guo C, Wang Q, Ge S, Qu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2305339
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2305339
FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway.
Hu Z, Dai J, Xu T, Chen H, Shen G, Zhou J, Ma H, Wang Y, Jin L
Respiratory research 2024 Feb 28;25(1):108
Respiratory research 2024 Feb 28;25(1):108
Cardioprotective effects of polydatin against myocardial injury in HFD/stz and high glucose-induced diabetes via a Caveolin 1-dependent mechanism.
Gong W, Zhang N, Sun X, Zhang Y, Wang Y, Lv D, Luo H, Liu Y, Chen Z, Lei Q, Zhao G, Bai L, Jiao Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156055
Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease.
Wang Y, Du Y, Huang H, Cao Y, Pan K, Zhou Y, He J, Yao W, Chen S, Gao X
Pharmacological research 2024 Apr;202:107133
Pharmacological research 2024 Apr;202:107133
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.
Gong W, Jiao Q, Yuan J, Luo H, Liu Y, Zhang Y, Chen Z, Xu X, Bai L, Zhang X
Clinical science (London, England : 1979) 2023 Mar 31;137(6):511-525
Clinical science (London, England : 1979) 2023 Mar 31;137(6):511-525
The role of 14-3-3 in the progression of vascular inflammation induced by lipopolysaccharide.
Tan H, Li J, Jia C, Huang H, Li L, Liao B, Long Y, Nie Y, Yu F
International immunopharmacology 2023 Jun;119:110220
International immunopharmacology 2023 Jun;119:110220
CTNNAL1 enhances glucocorticoid sensitivity in HDM-induced asthma mouse model through deactivating hsp90 signaling pathway.
Wu D, Liu L, Zhu J, Liu C, Long C, Liu C, Qu X, Liu H, Ji M, Qin X, Xiang Y
Life sciences 2023 Jan 15;313:121304
Life sciences 2023 Jan 15;313:121304
Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity.
Ma Z, Wei Y, Liao T, Jie L, Yang N, Yu L, Wang P
Journal of cellular and molecular medicine 2023 Dec;27(23):3773-3785
Journal of cellular and molecular medicine 2023 Dec;27(23):3773-3785
Hyperforin regulates renal fibrosis via targeting the PI3K-AKT/ICAM1 axis.
Yang S, Zhong S, Deng Z, Xie T, Yin G, Wang L, Liu J, Yang J, Long Z, Jiang X, Tan J
Cellular signalling 2023 Aug;108:110691
Cellular signalling 2023 Aug;108:110691
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
Lin Z, Li S, Xiao H, Xu Z, Li C, Zeng J, Wang S, Liu Z, Huang H
Cell reports 2023 Aug 29;42(8):112851
Cell reports 2023 Aug 29;42(8):112851
SARS-CoV-2 productively infects human brain microvascular endothelial cells.
Yang RC, Huang K, Zhang HP, Li L, Zhang YF, Tan C, Chen HC, Jin ML, Wang XR
Journal of neuroinflammation 2022 Jun 15;19(1):149
Journal of neuroinflammation 2022 Jun 15;19(1):149
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Chen J, Peng H, Chen C, Wang Y, Sang T, Cai Z, Zhao Q, Chen S, Lin X, Eling T, Wang X
Life sciences 2022 Dec 15;311(Pt A):121142
Life sciences 2022 Dec 15;311(Pt A):121142
Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus.
Wei J, Sun J, Zeng J, Ji E, Xu J, Tang C, Huo H, Zhang Y, Li H, Yang H
Frontiers in pharmacology 2021;12:604009
Frontiers in pharmacology 2021;12:604009
LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors.
Wang N, Hou SY, Qi X, Deng M, Cao JM, Tong BD, Xiong W
The Journal of clinical endocrinology and metabolism 2021 Jul 13;106(8):e2866-e2886
The Journal of clinical endocrinology and metabolism 2021 Jul 13;106(8):e2866-e2886
ICAM-1 Targeted Drug Combination Nanoparticles Enhanced Gemcitabine-Paclitaxel Exposure and Breast Cancer Suppression in Mouse Models.
Zhu L, Mu Q, Yu J, Griffin JI, Xu X, Ho RJY
Pharmaceutics 2021 Dec 31;14(1)
Pharmaceutics 2021 Dec 31;14(1)
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis.
Zhuang K, Jiang X, Liu R, Ye C, Wang Y, Wang Y, Quan S, Huang H
Frontiers in pharmacology 2020;11:616378
Frontiers in pharmacology 2020;11:616378
Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.
Liu Y, Zhang S, Li X, Liu E, Wang X, Zhou Q, Ye J, Wang JZ
Bioscience reports 2020 Feb 28;40(2)
Bioscience reports 2020 Feb 28;40(2)
Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain.
Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Cao F, Tian YK, Ye DW
Acta pharmacologica Sinica 2020 Aug;41(8):1041-1048
Acta pharmacologica Sinica 2020 Aug;41(8):1041-1048
Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.
Yang J, Zeng P, Liu L, Yu M, Su J, Yan Y, Ma J, Hu W, Yang X, Han J, Duan Y, Chen Y
Biochemical and biophysical research communications 2020 Apr 2;524(2):439-445
Biochemical and biophysical research communications 2020 Apr 2;524(2):439-445
The Selective RNA Polymerase I Inhibitor CX-5461 Mitigates Neointimal Remodeling in a Modified Model of Rat Aortic Transplantation.
Dai C, Sun M, Wang F, Zhu J, Wei Y, Guo X, Ma S, Dong B, Wang G, Jiang F, Wang J
Transplantation 2018 Oct;102(10):1674-1683
Transplantation 2018 Oct;102(10):1674-1683
Niaspan inhibits diabetic retinopathy‑induced vascular inflammation by downregulating the tumor necrosis factor‑α pathway.
Wang Y, Meng X, Yan H
Molecular medicine reports 2017 Mar;15(3):1263-1271
Molecular medicine reports 2017 Mar;15(3):1263-1271
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of 4T1 cells, using ICAM-1 antibody 16174-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line