GMA-8003

antibody from Green Mountain Antibodies

Targeting: F8 DXS1253E, F8C, FVIII, HEMA

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

GMA-8003

Provider

Green Mountain Antibodies

Product name

Anti-Factor VIII

Antibody type

Monoclonal

Antigen

Factor VIII

Description

GMA-8003 is a C2 domain specific antibody useful for detection of FVIII by ELISA. GMA-8003 is the designated cell line 2-117 as described by Meeks, S et al. in reference 1 and Summers, R et al. in reference 3.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

GMA-8003

Vial size

0.1mg, 0.5mg

References

Submitted references

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein.

Summers RJ, Meeks SL, Healey JF, Brown HC, Parker ET, Kempton CL, Doering CB, Lollar P
Blood 2011 Mar 17;117(11):3190-8

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Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation.

Meeks SL, Healey JF, Parker ET, Barrow RT, Lollar P
Blood 2007 Dec 15;110(13):4234-42

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Revision of the International Health Regulations. Progress Report, July 1997.

Releve epidemiologique hebdomadaire / Section d'hygiene du Secretariat de la Societe des Nations = Weekly epidemiological record / Health Section of the Secretariat of the League of Nations 1997 Jul 18;72(29):213-5