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- Antibody Data
- Antigen structure
- References [90]
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- Product number
- PA1669 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-NF-kB p65/RELA Antibody
- Antibody type
- Polyclonal
- Description
- Polyclonal antibody for NFkB p65/RELA detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. NFkB p65/RELA information: Molecular Weight: 60219 MW; Subcellular Localization: Nucleus. Cytoplasm. Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Vial size
- 100μg/vial
- Concentration
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Storage
- At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
- Handling
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Submitted references Baicalin-2-ethoxyethyl ester alleviates gentamicin-induced acute kidney injury via NF-κB signaling pathway.
Gut microbiota contribution to selenium deficiency-induced gut-liver inflammation.
Three Artemisia pollens trigger the onset of allergic rhinitis via TLR4/MyD88 signaling pathway.
Active fractions from Jingfang Baidu Powder alleviate Klebsiella-induced Pneumonia by inhibiting TLR4/Myd88-ERK signaling pathway.
Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways.
Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system.
Hippophae rhamnoides reverses decreased CYP2D6 expression in rats with BCG-induced liver injury.
Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway.
Sirt4 deficiency promotes the development of atherosclerosis by activating the NF-κB/IκB/CXCL2/3 pathway.
Deletion of Brucella transcriptional regulator GntR10 regulated the expression of quorum sensing system and type IV secretion system effectors, which affected the activation of NF-κB.
Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking and in vivo experimental verification.
Sirtuin1 inhibits calcium oxalate crystal-induced kidney injury by regulating TLR4 signaling and macrophage-mediated inflammatory activation.
UHPLC-MS-Based Metabolomics Reveal the Potential Mechanism of Armillaria mellea Acid Polysaccharide in and Its Effects on Cyclophosphamide-Induced Immunosuppressed Mice.
Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155/TRAF3/ROS pathway.
Active ingredients screening and pharmacological mechanism research of curcumae rhizoma-sparganii rhizoma herb pair ameliorates liver fibrosis based on network pharmacology.
Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway.
Using extracellular vesicles derived from human umbilical cord mesenchymal stem cells for a topical coating promotes oral mucositis healing in rats.
Human Neural Stem Cell Secretome Inhibits Lipopolysaccharide-Induced Neuroinflammation Through Modulating Microglia Polarization by Activating Peroxisome Proliferator-Activated Receptor Gamma.
Folic acid ameliorates N-methyl-N'-nitro-N-nitrosoguanidine-induced esophageal inflammation via modulation of the NF-κB pathway.
Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes.
Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling.
HMGB1 promotes Ox-LDL-induced endothelial cell damage by inhibiting PI3K/Akt signaling pathway.
Short-Chain Fatty Acids Weaken Ox-LDL-Induced Cell Inflammatory Injury by Inhibiting the NLRP3/Caspase-1 Pathway and Affecting Cellular Metabolism in THP-1 Cells.
An Acidic Polysaccharide with Anti-Inflammatory Effects from Blackened Jujube: Conformation and Rheological Properties.
Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3.
Combination of cyclophosphamide and shengbai decoction has synergistic effect against melanoma.
Paeonol antagonizes oncogenesis of osteosarcoma by inhibiting the function of TLR4/MAPK/NF-κB pathway.
Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer.
Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulating matrix metalloproteinase 1 expression through inhibition of the ERK1/2/NF-κB signalling pathway.
NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways.
Partial liquid ventilation-induced mild hypothermia improves the lung function and alleviates the inflammatory response during acute respiratory distress syndrome in canines.
Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling.
Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.
Total flavonoids, extracted from Polygonum knotweed L, exert beneficial hepatoprotection against liver injury.
The CXCL12-CXCR4 axis promotes migration, invasiveness, and EMT in human papillary thyroid carcinoma B-CPAP cells via NF-κB signaling.
Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice.
Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signalling pathway in a rat model.
Isolation, purification, structural characterization and immunostimulatory activity of water-soluble polysaccharides from Lepidium meyenii.
Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in d-galactose-induced aging mice.
Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.
Red nucleus interleukin-1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways.
Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish.
Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway.
Silencing of Y-box binding protein-1 by RNA interference inhibits proliferation, invasion, and metastasis, and enhances sensitivity to cisplatin through NF-κB signaling pathway in human neuroblastoma SH-SY5Y cells.
Epigallocatechin-3-gallate attenuates neointimal hyperplasia in a rat model of carotid artery injury by inhibition of high mobility group box 1 expression.
Orientin Attenuates Cerebral Ischemia/Reperfusion Injury in Rat Model through the AQP-4 and TLR4/NF-κB/TNF-α Signaling Pathway.
Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats.
Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats.
Unfractionated heparin protects the protein C system against lipopolysaccharide-induced damage in vivo and in vitro.
MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells.
The vascular protective effects of Anoectochilus roxburghii polysaccharose under high glucose conditions.
Gypenoside Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of Mitogen-Activated Protein Kinase Mediated Nuclear Factor Kappa B Pathway In Vitro and In Vivo.
Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB.
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Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway.
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Deletion of Brucella transcriptional regulator GntR10 regulated the expression of quorum sensing system and type IV secretion system effectors, which affected the activation of NF-κB.
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Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking and in vivo experimental verification.
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Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155/TRAF3/ROS pathway.
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Active ingredients screening and pharmacological mechanism research of curcumae rhizoma-sparganii rhizoma herb pair ameliorates liver fibrosis based on network pharmacology.
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Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway.
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Folic acid ameliorates N-methyl-N'-nitro-N-nitrosoguanidine-induced esophageal inflammation via modulation of the NF-κB pathway.
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Toxicology and applied pharmacology 2022 Jul 15;447:116087
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Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling.
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HMGB1 promotes Ox-LDL-induced endothelial cell damage by inhibiting PI3K/Akt signaling pathway.
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Short-Chain Fatty Acids Weaken Ox-LDL-Induced Cell Inflammatory Injury by Inhibiting the NLRP3/Caspase-1 Pathway and Affecting Cellular Metabolism in THP-1 Cells.
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An Acidic Polysaccharide with Anti-Inflammatory Effects from Blackened Jujube: Conformation and Rheological Properties.
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Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3.
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Combination of cyclophosphamide and shengbai decoction has synergistic effect against melanoma.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:109866
Paeonol antagonizes oncogenesis of osteosarcoma by inhibiting the function of TLR4/MAPK/NF-κB pathway.
Zhou J, Liu Q, Qian R, Liu S, Hu W, Liu Z
Acta histochemica 2020 Jan;122(1):151455
Acta histochemica 2020 Jan;122(1):151455
Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer.
Li D, Ji H, Niu X, Yin L, Wang Y, Gu Y, Wang J, Zhou X, Zhang H, Zhang Q
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Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulating matrix metalloproteinase 1 expression through inhibition of the ERK1/2/NF-κB signalling pathway.
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NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways.
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Partial liquid ventilation-induced mild hypothermia improves the lung function and alleviates the inflammatory response during acute respiratory distress syndrome in canines.
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Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling.
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Molecular and cellular biochemistry 2019 Nov;461(1-2):205-212
Molecular and cellular biochemistry 2019 Nov;461(1-2):205-212
Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.
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Inflammopharmacology 2019 Aug;27(4):809-816
Inflammopharmacology 2019 Aug;27(4):809-816
Total flavonoids, extracted from Polygonum knotweed L, exert beneficial hepatoprotection against liver injury.
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Journal of cellular biochemistry 2019 Aug;120(8):12677-12683
Journal of cellular biochemistry 2019 Aug;120(8):12677-12683
The CXCL12-CXCR4 axis promotes migration, invasiveness, and EMT in human papillary thyroid carcinoma B-CPAP cells via NF-κB signaling.
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Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice.
Fu CL, Liu Y, Leng J, Zhang J, He YF, Chen C, Wang Z, Li W
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Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signalling pathway in a rat model.
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British journal of pharmacology 2018 Mar;175(6):859-876
British journal of pharmacology 2018 Mar;175(6):859-876
Isolation, purification, structural characterization and immunostimulatory activity of water-soluble polysaccharides from Lepidium meyenii.
Zha Z, Wang SY, Chu W, Lv Y, Kan H, Chen Q, Zhong L, Yue L, Xiao J, Wang Y, Yin H
Phytochemistry 2018 Mar;147:184-193
Phytochemistry 2018 Mar;147:184-193
Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in d-galactose-induced aging mice.
Zhou H, Qu Z, Zhang J, Jiang B, Liu C, Gao W
RSC advances 2018 Mar 13;8(19):10163-10171
RSC advances 2018 Mar 13;8(19):10163-10171
Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.
Wu K, Fan J, Huang X, Wu X, Guo C
International journal of biological macromolecules 2018 Jul 15;114:137-142
International journal of biological macromolecules 2018 Jul 15;114:137-142
Red nucleus interleukin-1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways.
Guo YJ, Li HN, Ding CP, Han SP, Wang JY
Journal of neuroscience research 2018 Dec;96(12):1847-1861
Journal of neuroscience research 2018 Dec;96(12):1847-1861
Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish.
Li JJ, Zhang Y, Han LW, Tian QP, He QX, Wang XM, Sun C, Han J, Liu KC
Fish & shellfish immunology 2018 Dec;83:205-212
Fish & shellfish immunology 2018 Dec;83:205-212
Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway.
Xu W, Zheng D, Liu Y, Li J, Yang L, Shang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2091-2104
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2091-2104
Silencing of Y-box binding protein-1 by RNA interference inhibits proliferation, invasion, and metastasis, and enhances sensitivity to cisplatin through NF-κB signaling pathway in human neuroblastoma SH-SY5Y cells.
Wang H, Sun R, Chi Z, Li S, Hao L
Molecular and cellular biochemistry 2017 Sep;433(1-2):1-12
Molecular and cellular biochemistry 2017 Sep;433(1-2):1-12
Epigallocatechin-3-gallate attenuates neointimal hyperplasia in a rat model of carotid artery injury by inhibition of high mobility group box 1 expression.
Yang B, Gao P, Wu X, Yu J, Li Y, Meng R, Li Y, Yan J, Jin X
Experimental and therapeutic medicine 2017 Sep;14(3):1975-1982
Experimental and therapeutic medicine 2017 Sep;14(3):1975-1982
Orientin Attenuates Cerebral Ischemia/Reperfusion Injury in Rat Model through the AQP-4 and TLR4/NF-κB/TNF-α Signaling Pathway.
Wang X, An F, Wang S, An Z, Wang S
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Oct;26(10):2199-2214
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Oct;26(10):2199-2214
Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats.
Sun G, Yang W, Zhang Y, Zhao M
Experimental animals 2017 Oct 30;66(4):303-312
Experimental animals 2017 Oct 30;66(4):303-312
Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats.
Liu X, Zhang J, Han W, Wang Y, Liu Y, Zhang Y, Zhou D, Xiang L
Molecular medicine reports 2017 Jul;16(1):192-200
Molecular medicine reports 2017 Jul;16(1):192-200
Unfractionated heparin protects the protein C system against lipopolysaccharide-induced damage in vivo and in vitro.
Zhao D, Ding R, Liu Y, Yin X, Zhang Z, Ma X
Experimental and therapeutic medicine 2017 Dec;14(6):5515-5522
Experimental and therapeutic medicine 2017 Dec;14(6):5515-5522
MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells.
Chen C, Jiang X, Gu S, Zhang Z
Toxicology letters 2017 Aug 15;278:38-47
Toxicology letters 2017 Aug 15;278:38-47
The vascular protective effects of Anoectochilus roxburghii polysaccharose under high glucose conditions.
Liu ZL, Zhang JG, Liu Q, Yi LT, Li YM, Li Y
Journal of ethnopharmacology 2017 Apr 18;202:192-199
Journal of ethnopharmacology 2017 Apr 18;202:192-199
Gypenoside Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of Mitogen-Activated Protein Kinase Mediated Nuclear Factor Kappa B Pathway In Vitro and In Vivo.
Yu H, Shi L, Qi G, Zhao S, Gao Y, Li Y
Frontiers in pharmacology 2016;7:148
Frontiers in pharmacology 2016;7:148
Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB.
Li Y, Zhang Q, Qi D, Zhang L, Yi L, Li Q, Zhang Z
The journal of headache and pain 2016;17:49
The journal of headache and pain 2016;17:49
Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects.
Han J, Xie Y, Sui F, Liu C, Du X, Liu C, Feng X, Jiang D
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Molecular medicine reports 2016 Sep;14(3):2589-97
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- Main image
- Experimental details
- Anti-NF-kB p65 antibody, PA1669, Western blottingLane 1: Rat Testis Tissue Lysate Lane 2: HELA Cell Lysate Lane 3: A431 Cell Lysate Lane 4: JURKAT Cell Lysate
- Additional image
