BS8986

antibody from Bioworld Technology, Inc
Targeting: PBX1
Provider product page for BS8986
Western blot
Immunohistochemistry

Antibody data

Product number
BS8986 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PBX1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Pre-B-cell leukemia transcription factor 1; Homeobox protein PBX1; Homeobox protein PRL; PBX1; PRL
Description
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PBX1 protein structure - BS8986 shown in red.