23274-1-AP

antibody from Proteintech Group

Targeting: PINK1 BRPK, PARK6

Provider product page for 23274-1-AP

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Product number: 23274-1-AP - Provider product page
Provider: Proteintech Group
Product name: PINK1 antibody
Antibody type: Polyclonal
Description: KD/KO validated PINK1 antibody (Cat. #23274-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PINK1 protein structure - 23274-1-AP shown in red.

Submitted references Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.

Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697

Bombyx mori cypovirus (BmCPV) induces PINK1-Parkin mediated mitophagy via interaction of VP4 with host Tom40.

Zhu M, Pan J, Zhang M, Tong X, Zhang Y, Zhang Z, Liang Z, Zhang X, Hu X, Xue R, Cao G, Gong C
Developmental and comparative immunology 2022 Jan;126:104244

Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.

Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660

Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.

Zhao L, Liu D, Ma W, Gu H, Wei X, Luo W, Yuan Z
Frontiers in cell and developmental biology 2021;9:644346

Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes.

Xu R, Kang L, Wei S, Yang C, Fu Y, Ding Z, Zou Y
Frontiers in cardiovascular medicine 2021;8:748156

Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy.

Cai M, Du B, Si Y, Miao J, Ge J, Zhang J, Song J, Bao H
American journal of translational research 2021;13(7):7538-7555

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.

Ji W, Wan T, Zhang F, Zhu X, Guo S, Mei X
Frontiers in pharmacology 2021;12:641058

Astragaloside II Ameliorated Podocyte Injury and Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats.

Su J, Gao C, Xie L, Fan Y, Shen Y, Huang Q, Wang N, Xu Y, Yang N, Gui D
Frontiers in pharmacology 2021;12:638422

A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.

Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15

HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia.

Li X, Wang M, Li S, Chen Y, Wang M, Wu Z, Sun X, Yao L, Dong H, Song Y, Xu Y
Theranostics 2021;11(15):7337-7359

Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.

Zhang W, You B, Qi D, Qiu L, Ripley-Gonzalez JW, Zheng F, Fu S, Li C, Dun Y, Liu S
Scientific reports 2021 Sep 27;11(1):19116

The protection of selenium against cadmium-induced mitophagy via modulating nuclear xenobiotic receptors response and oxidative stress in the liver of rabbits.

Zhang L, Yang F, Li Y, Cao H, Huang A, Zhuang Y, Zhang C, Hu G, Mao Y, Luo J, Xing C
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117301

Moderate mechanical stress suppresses the IL-1β-induced chondrocyte apoptosis by regulating mitochondrial dynamics.

Zhang J, Hao X, Chi R, Qi J, Xu T
Journal of cellular physiology 2021 Nov;236(11):7504-7515

Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide.

Wang N, Zhu P, Huang R, Sun L, Dong D, Gao Y
Experimental and therapeutic medicine 2021 Nov;22(5):1246

Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.

Li M, Cheng W, Zhang L
Metallomics : integrated biometal science 2021 Nov 19;13(11)

Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.

Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723

Biosynthetic gold nanoparticles of Hibiscus syriacus L. callus potentiates anti-inflammation efficacy via an autophagy-dependent mechanism.

Xu XY, Tran THM, Perumalsamy H, Sanjeevram D, Kim YJ
Materials science & engineering. C, Materials for biological applications 2021 May;124:112035

PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca²⁺ efflux.

Zhou Q, Xie M, Zhu J, Yi Q, Tan B, Li Y, Ye L, Zhang X, Zhang Y, Tian J, Xu H
Stem cell research & therapy 2021 May 6;12(1):269

Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/Parkin-mediated mitophagy.

Xi J, Rong Y, Zhao Z, Huang Y, Wang P, Luan H, Xing Y, Li S, Liao J, Dai Y, Liang J, Wu F
Journal of ethnopharmacology 2021 May 10;271:113855

Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.

Guan R, Li Z, Dai X, Zou W, Yu X, Liu H, Chen Q, Teng W, Liu P, Liu X, Dong S
Molecular medicine reports 2021 Jul;24(1)

Autophagy regulates functional differentiation of mammary epithelial cells.

Elswood J, Pearson SJ, Payne HR, Barhoumi R, Rijnkels M, W Porter W
Autophagy 2021 Feb;17(2):420-438

Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR^mt in the hypothalamus of mice.

Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER
Scientific reports 2021 Feb 15;11(1):3813

Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway.

Wang Z, Feng F, He H, Wu Q, Gu C, Hrovat J, Peng W, Xu Y, Han D, Yang P, Zhou X, Li J, Shan J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Aug;89:153599

Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity.

Dhandapani S, Xu X, Wang R, Puja AM, Kim H, Perumalsamy H, Balusamy SR, Kim YJ
Materials science & engineering. C, Materials for biological applications 2021 Aug;127:112214

Effects of the Cytoplasm and Mitochondrial Specific Hydroxyl Radical Scavengers TA293 and mitoTA293 in Bleomycin-Induced Pulmonary Fibrosis Model Mice.

Sakai T, Takagaki H, Yamagiwa N, Ui M, Hatta S, Imai J
Antioxidants (Basel, Switzerland) 2021 Aug 31;10(9)

An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells.

Yu S, Yan X, Tian R, Xu L, Zhao Y, Sun L, Su J
International journal of molecular sciences 2021 Apr 13;22(8)

Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells.

Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B
Cancer treatment and research communications 2020;25:100210

Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.

Wang X, Zhang JQ, Xiu CK, Yang J, Fang JY, Lei Y
Oxidative medicine and cellular longevity 2020;2020:7151946

Bcl-2 Proteins Regulate Mitophagy in Lipopolysaccharide-Induced Acute Lung Injury via PINK1/Parkin Signaling Pathway.

Zhang Z, Chen Z, Liu R, Liang Q, Peng Z, Yin S, Tang J, Gong T, Liu Y
Oxidative medicine and cellular longevity 2020;2020:6579696

Deletion of mitochondrial uncoupling protein 2 exacerbates mitophagy and cell apoptosis after cerebral ischemia and reperfusion injury in mice.

He M, Zhang T, Fan Y, Ma Y, Zhang J, Jing L, Li PA
International journal of medical sciences 2020;17(17):2869-2878

Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy.

Hu X, Wang J, Chai J, Yu X, Zhang Y, Feng Y, Qin J, Yu H
OncoTargets and therapy 2020;13:9967-9976

Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy.

Zhou HR, Ma XF, Lin WJ, Hao M, Yu XY, Li HX, Xu CY, Kuang HY
Frontiers in pharmacology 2020;11:589114

Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.

Chen L, Liao F, Jiang Z, Zhang C, Wang Z, Luo P, Jiang Q, Wu J, Wang Q, Luo M, Li X, Leng Y, Ma L, Shen G, Chen Z, Wang Y, Tan X, Gan Y, Liu D, Liu Y, Shi C
British journal of pharmacology 2020 Sep;177(17):3991-4006

miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin/Ambra1 signaling.

Zhou J, Zhao Y, Li Z, Zhu M, Wang Z, Li Y, Xu T, Feng D, Zhang S, Tang F, Yao J
Pharmacological research 2020 Oct;160:105197

Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.

Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA
EMBO molecular medicine 2020 Oct 7;12(10):e12146

Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2.

Gao Z, Mei J, Yan X, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 15;333:261-268

Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.

Wang Z, Xu JH, Mou JJ, Kong XT, Zou JW, Xue HL, Wu M, Xu LX
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766

Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway.

Jia X, Qiu T, Yao X, Jiang L, Wang N, Wei S, Tao Y, Pei P, Wang Z, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X
Journal of hazardous materials 2020 Nov 15;399:123034

Treadmill Exercise Attenuates Aβ-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP/PS1 Transgenic Mice.

Zhao N, Yan QW, Xia J, Zhang XL, Li BX, Yin LY, Xu B
Neurochemical research 2020 May;45(5):1202-1214

Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.

Tian Y, Guo H, Miao X, Xu J, Yang R, Zhao L, Liu J, Yang L, Gao F, Zhang W, Liu Q, Sun S, Tian Y, Li H, Huang J, Gu C, Liu S, Feng X
Cell death & disease 2020 May 5;11(5):319

Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells.

Si L, Fu J, Liu W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T
Archives of biochemistry and biophysics 2020 May 30;685:108284

FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway.

Li C, Zhou J, Liu Z, Zhou J, Yao W, Tao J, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3631-3645

lncRNA RMST Suppressed GBM Cell Mitophagy through Enhancing FUS SUMOylation.

Liu C, Peng Z, Li P, Fu H, Feng J, Zhang Y, Liu T, Liu Y, Liu Q, Liu Q, Li D, Wu M
Molecular therapy. Nucleic acids 2020 Mar 6;19:1198-1208

ChREBP-β regulates thermogenesis in brown adipose tissue.

Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356

DNA damage invokes mitophagy through a pathway involving Spata18.

Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG, Croteau DL, Bohr VA
Nucleic acids research 2020 Jul 9;48(12):6611-6623

Qiliqiangxin reduced cardiomyocytes apotosis and improved heart function in infarcted heart through Pink1/Parkin -mediated mitochondrial autophagy.

Zhou J, Wang Z, He Y, Luo X, Zhang W, Yu L, Chen X, He X, Yuan Y, Wang X, Guo X, Tang J, Zhu M, Li D, Ding Y
BMC complementary medicine and therapies 2020 Jul 2;20(1):203

Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies.

Liang C, Gao Y, He Y, Han Y, Manthari RK, Tikka C, Chen C, Wang J, Zhang J
Environmental pollution (Barking, Essex : 1987) 2020 Jan;256:113438

Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.

Xia B, Yu J, He T, Liu X, Su J, Wang M, Wang J, Zhu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839

NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis.

Zhao W, Zhang W, Ma H, Yang M
Scientific reports 2020 Feb 20;10(1):3078

Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.

Unno R, Kawabata T, Taguchi K, Sugino T, Hamamoto S, Ando R, Okada A, Kohri K, Yoshimori T, Yasui T
Autophagy 2020 Apr;16(4):709-723

Exogenous H₂S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.

Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285

FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.

Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763

PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.

Zhao C, He R, Shen M, Zhu F, Wang M, Liu Y, Chen H, Li X, Qin R
Frontiers in pharmacology 2019;10:968

Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis.

Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC
Frontiers in endocrinology 2019;10:320

Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway.

Yin F, Yan J, Zhao Y, Guo KJ, Zhang ZL, Li AP, Meng CY, Guo L
Ecotoxicology and environmental safety 2019 Jul 30;176:234-241

Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.

Yu X, Hao M, Liu Y, Ma X, Lin W, Xu Q, Zhou H, Shao N, Kuang H
European journal of pharmacology 2019 Dec 1;864:172715

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.

Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S
Autophagy 2018;14(2):311-335

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Fu T, Xu Z, Liu L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu MS, Chen Q, Gan Z
Cell reports 2018 May 1;23(5):1357-1372

PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver.

Xiao Y, Zhou Y, Lu Y, Zhou K, Cai W
Cell death & disease 2018 Feb 7;9(2):160

Involvement of PINK1/Parkin-mediated mitophagy in paraquat- induced apoptosis in human lung epithelial-like A549 cells.

Sun DZ, Song CQ, Xu YM, Wang R, Liu W, Liu Z, Dong XS
Toxicology in vitro : an international journal published in association with BIBRA 2018 Dec;53:148-159

Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.

Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554

Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.

Scott TL, Wicker CA, Suganya R, Dhar B, Pittman T, Horbinski C, Izumi T
Molecular carcinogenesis 2017 Feb;56(2):325-336

ABT737 induces mitochondrial pathway apoptosis and mitophagy by regulating DRP1-dependent mitochondrial fission in human ovarian cancer cells.

Yu Y, Xu L, Qi L, Wang C, Xu N, Liu S, Li S, Tian H, Liu W, Xu Y, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:22-29

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