GPA33

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

Description

Glycoprotein A33

Tissue specificity

Tissue enriched (intestine)

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (167052836 - 167166479)

Ensembl ID

ENSG00000143167  (ver. 103.38)

Orthologs

Mouse Gpa33: ENSMUSG00000000544

UniProt

Q99795

neXtProt

NX_Q99795

Human splice variants
Mouse splice variants

Protein structure