SDR16C5

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

Short chain dehydrogenase/reductase family 16C member 5

Tissue specificity

Tissue enhanced (esophagus, lung, skin)

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (56300005 - 56320776)

Ensembl ID

ENSG00000170786  (ver. 103.38)

Orthologs

Mouse Sdr16c5: ENSMUSG00000028236

UniProt

Q8N3Y7

neXtProt

NX_Q8N3Y7

Human splice variants
Mouse splice variants

Protein structure