Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AB-406-NA - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal IL-6 Antibody
- Antibody type
- Polyclonal
- Description
- Protein A or G purified. Detects mouse IL-6 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant rat IL-6 is observed and less than 5% cross-reactivity with recombinant human IL-6, recombinant feline IL-6, recombinant bovine IL-6, and recombinant porcine IL-6 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 1 mg
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Maladaptive role of IL-6 in ischemic acute renal failure.
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A
Nature 2019 Oct;574(7779):553-558
Nature 2019 Oct;574(7779):553-558
Maladaptive role of IL-6 in ischemic acute renal failure.
Kielar ML, John R, Bennett M, Richardson JA, Shelton JM, Chen L, Jeyarajah DR, Zhou XJ, Zhou H, Chiquett B, Nagami GT, Lu CY
Journal of the American Society of Nephrology : JASN 2005 Nov;16(11):3315-25
Journal of the American Society of Nephrology : JASN 2005 Nov;16(11):3315-25
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by IL-6 and Neutralization by Mouse IL-6 Antibody. Recombinant Mouse IL-6 (Catalog # 406-ML) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-6 (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL-6 Polyclonal Antibody (Catalog # AB-406-NA). The ND50 is typically 0.05-0.15 µg/mL.