313210

antibody from BioLegend

Targeting: KIT C-Kit, CD117, PBT, SCFR

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

313210

Provider

BioLegend

Proper citation

BioLegend Cat#313210, RRID:AB_893223

Product name

PE/Cy5 anti-human CD117 (c-kit)

Antibody type

Monoclonal

Antigen

MOLM-1 megakaryocytic cell line

Description

CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemic cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.

Reactivity

Human, Bovine, Simian

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

100 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

References

Submitted references

Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood.

Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, Shibuya M, Yoshikawa H, Ohneda O
Blood 2007 Jul 1;110(1):151-60

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human myeloid leukemia cell line TF-1 stained with 104D2 PE/Cy5

Conjugate

Yellow dye