KRT2

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Description

Keratin 2

Tissue specificity

Tissue enriched (skin)

Subcell location

Golgi apparatus, Intermediate filaments, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (52644558 - 52652211)

Ensembl ID

ENSG00000172867  (ver. 103.38)

Orthologs

Mouse Krt2: ENSMUSG00000064201

UniProt

P35908

neXtProt

NX_P35908

Human splice variants
Mouse splice variants

Protein structure