518303

antibody from BioLegend

Targeting: C5 C5a, C5b, CPAMD4

Western blot (Recommended by provider)

ELISA (Data presented on provider website)

Immunoprecipitation (Recommended by provider)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

518303

Provider

BioLegend

Proper citation

BioLegend Cat#518303, RRID:AB_10900266

Product name

LEAF™ Purified anti-human C5a/C5a(desArg)/C5 [G25/2]

Antibody type

Monoclonal

Antigen

Human C5a

Description

C5, complement component 5, is a protein involved in the complement system. It is cleaved into C5a and C5b by the C3/C5 convertase. The smaller fragment C5a is an anaphylatoxin and  is released into the fluid surroundings. C5a is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). C5a contains 74 amino acids and is rapidly metabolised by a serum enzyme, carboxypeptidase B to a 73 amino acid form, C5a des-Arg. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 µg

Concentration

1 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.