518306

antibody from BioLegend

Targeting: C5 C5a, C5b, CPAMD4

Western blot (Recommended by provider)

ELISA (Data presented on provider website)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

518306

Provider

BioLegend

Proper citation

BioLegend Cat#518306, RRID:AB_10896948

Product name

Biotin anti-human C5a/C5a(desArg)/C5

Antibody type

Monoclonal

Antigen

Human C5a

Description

C5, complement component 5, is a protein involved in the complement system. It is cleaved into C5a and C5b by the C3/C5 convertase. The smaller fragment C5a is an anaphylatoxin and  is released into the fluid surroundings. C5a is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). C5a contains 74 amino acids and is rapidly metabolised by a serum enzyme, carboxypeptidase B to a 73 amino acid form, C5a des-Arg. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.

Reactivity

Human

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Vial size

500 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.