KLK10

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Description

Kallikrein related peptidase 10

Tissue specificity

Group enriched (esophagus, vagina)

Predicted location

Secreted in other tissues

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

19 (51012739 - 51020175)

Ensembl ID

ENSG00000129451  (ver. 103.38)

Orthologs

Mouse Klk10: ENSMUSG00000030693

UniProt

O43240

neXtProt

NX_O43240

Human splice variants
Mouse splice variants

Protein structure