Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 17707-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17707-1-AP, RRID:AB_2272676
- Product name
- USP28 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP28 antibody (Cat. #17707-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells.
A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation.
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification.
Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer.
Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
The stability and oncogenic function of LIN28A are regulated by USP28.
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.
The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells.
Wang J, Dong Y, Ma H, Wu L, Zhen X, Tang L, Jin J, Han S, Zhang P, Peng J
The Journal of biological chemistry 2021 Nov 22;298(1):101443
The Journal of biological chemistry 2021 Nov 22;298(1):101443
A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation.
Li S, Zhang L, Zhang G, Shangguan G, Hou X, Duan W, Xi Y, Xu N, Zhang B, Dong J, Wang Y, Cui W, Chen S
iScience 2021 Nov 19;24(11):103296
iScience 2021 Nov 19;24(11):103296
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification.
Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ
The EMBO journal 2021 Feb 15;40(4):e105106
The EMBO journal 2021 Feb 15;40(4):e105106
Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
Yan D, Li X, Yang Q, Huang Q, Yao L, Zhang P, Sun W, Lin S, Dou QP, Liu J, Chen X
Cell death discovery 2021 Aug 11;7(1):211
Cell death discovery 2021 Aug 11;7(1):211
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
Gerakopoulos V, Ngo P, Tsiokas L
Life science alliance 2020 Sep;3(9)
Life science alliance 2020 Sep;3(9)
Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer.
Li P, Huang Z, Wang J, Chen W, Huang J
OncoTargets and therapy 2019;12:1603-1611
OncoTargets and therapy 2019;12:1603-1611
Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Gersch M, Wagstaff JL, Toms AV, Graves B, Freund SMV, Komander D
Molecular cell 2019 May 2;74(3):436-451.e7
Molecular cell 2019 May 2;74(3):436-451.e7
The stability and oncogenic function of LIN28A are regulated by USP28.
Haq S, Das S, Kim DH, Chandrasekaran AP, Hong SH, Kim KS, Ramakrishna S
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):599-610
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):599-610
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.
Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ
The Journal of cell biology 2016 Jul 18;214(2):143-53
The Journal of cell biology 2016 Jul 18;214(2):143-53
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.
Diefenbacher ME, Popov N, Blake SM, Schülein-Völk C, Nye E, Spencer-Dene B, Jaenicke LA, Eilers M, Behrens A
The Journal of clinical investigation 2014 Aug;124(8):3407-18
The Journal of clinical investigation 2014 Aug;124(8):3407-18
The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells.
Wu Y, Wang Y, Yang XH, Kang T, Zhao Y, Wang C, Evers BM, Zhou BP
Cell reports 2013 Oct 17;5(1):224-36
Cell reports 2013 Oct 17;5(1):224-36
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17707-1-AP(USP28 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 17707-1-AP(USP28 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP28 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP28. This antibody recognizes human,mouse,rat antigen. The USP28 antibody has been validated for the following applications: ELISA, WB, IHC analysis.