TRIT1

This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]

Description

TRNA isopentenyltransferase 1

Tissue specificity

Low tissue specificity

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (39838110 - 39883511)

Ensembl ID

ENSG00000043514  (ver. 103.38)

Orthologs

Mouse Trit1: ENSMUSG00000028653

UniProt

Q9H3H1

neXtProt

NX_Q9H3H1

Human splice variants
Mouse splice variants

Protein structure