RNASE1

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Description

Ribonuclease A family member 1, pancreatic

Tissue specificity

Tissue enriched (pancreas)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Secreted to digestive system

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (20801228 - 20802855)

Ensembl ID

ENSG00000129538  (ver. 103.38)

Orthologs

Mouse Rnase1: ENSMUSG00000035896

UniProt

P07998

neXtProt

NX_P07998

Human splice variants
Mouse splice variants

Protein structure