675702

antibody from BioLegend
Targeting: MMP1 CLG
Provider product page for 675702

Antibody data

Product number
675702 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#675702, RRID:AB_2565606
Product name
Purified anti-MMP1
Antibody type
Monoclonal
Antigen
Recombinant human MMP-1.
Description
Members of the matrix metalloproteinase family proteins (MMPs) are structurally related and zinc-containing enzymes that not only degrade the extracellular matrix (ECM) and connective tissue proteins under normal physiological setting but also during disease (e.g. arthritis and metastasis). The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. MMP1 consists of a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin-like repeats) domain. It is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction. Substrates of MMP-1 include collagen I, II, III, VII, VIII, and X as well as casein, gelatin, alpha1 antitrypsin, myelin basic protein, L Selectin, pro-TNF, IL-1β, IGFBP3, IGFBP5, pro-MMP-2, and pro-MMP-9. In addition, chemokines are substrates for MMP-1. CCL2, CCL7, CCL8, and CCL13 are catalytically cleaved by MMP-1 to produce receptor antagonists. CXCL5 and CXCL12 are also substrates for MMP1. TIMPs inhibit MMPs in a 1:1 inhibitor to enzyme ratio through interaction of the N-terminal domain of the TIMP molecule with the active site of the MMP. MMP1 is overexpressed in invasive melanoma, colorectal, and esophageal cancers. Importantly, MMP-1 expression was shown to increase progressively with tumor stage.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
M4110F03
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
MMP1 protein structure - 675702 shown in red.