ATXN2

gene product
ATX2, SCA2, TNRC13
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined. [provided by RefSeq, Jan 2010]
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74 antibodies from 17 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
antibodies-online
35 antibodies
Bethyl Laboratories, Inc.
1 antibody
Novus Biologicals
5 antibodies
Atlas Antibodies
3 antibodies
Aviva Systems Biology
3 antibodies
RabMAbs
1 antibody
LifeSpan BioSciences, Inc.
8 antibodies
Biorbyt
4 antibodies
Bioworld Technology, Inc
1 antibody
Sigma-Aldrich
3 antibodies
Creative Biomart
3 antibodies
Abnova Corporation
2 antibodies
Boster Immunoleader Biotechnology
1 antibody
Everest Biotech
1 antibody
GeneTex
1 antibody
United States Biological
1 antibody