168

antibody from YO Proteins AB

Targeting: PLAU UPA, URK

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

168

Provider

YO Proteins AB

Proper citation

YO Proteins Cat#168, RRID:AB_2165333

Product name

Rabbit anti-human urokinase polyclonal antibody

Antibody type

Polyclonal

Description

Polyclonal rabbit antibody anti-human urokinase (abbokinase, urokinase-type Plasminogen Activator, uPA). The antibody binds to human HMW-scuPA (54 kDa), HMW-tsuPA (52 kDa) and LMW-scuPA (33 kDa) with high apparent affinity (Kd= 0.1 nM) completely inhibiting the ability of urokinase to activate plasminogen. Urokinase reaction with synthetic substrate S2444 is also inhibited. The antibody is highly specific for urokinase, no crossreactions were found with other serine proteases (tissue plasminogen activator, plasmin, trypsin, chymotrypsin, elastase, thrombin). Human whole plasma or plasma proteins do not interfere with its binding to urokinase

Host

Rabbit

Conjugate

Unconjugated

Vial size

1 ml

References

Submitted references

Plasmin in nephrotic urine activates the epithelial sodium channel.

Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skøtt O
Journal of the American Society of Nephrology : JASN 2009 Feb;20(2):299-310

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FAP-alpha and uPA show different expression patterns in premalignant and malignant esophageal lesions.

Goscinski MA, Suo Z, Flørenes VA, Vlatkovic L, Nesland JM, Giercksky KE
Ultrastructural pathology 2008 May-Jun;32(3):89-96