RNF43

The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Description

Ring finger protein 43

Tissue specificity

Tissue enhanced (intestine)

Predicted location

Membrane

Protein family

Cancer-related genes
Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins

Chromosome

17 (58353676 - 58417595)

Ensembl ID

ENSG00000108375  (ver. 103.38)

Orthologs

-

UniProt

Q68DV7

neXtProt

NX_Q68DV7

Human splice variants

Protein structure