TSHB

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Description

Thyroid stimulating hormone subunit beta

Tissue specificity

Tissue enriched (pituitary gland)

Predicted location

Secreted to blood

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

1 (115029826 - 115034302)

Ensembl ID

ENSG00000134200  (ver. 103.38)

Orthologs

Mouse Tshb: ENSMUSG00000027857

UniProt

P01222

neXtProt

NX_P01222

Human splice variants
Mouse splice variants

Protein structure