351006

antibody from BioLegend
Targeting: CD276 B7-H3, B7H3, B7RP-2
Provider product page for 351006

Antibody data

Product number
351006 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#351006, RRID:AB_2564404
Product name
APC anti-human CD276 (B7-H3)
Antibody type
Monoclonal
Antigen
Human B7-H3
Description
B7-H3, assigned as CD276, is a type I transmembrane protein and shares 20-27% amino acid identity with other B7 family members. Human B7-H3 has a single extracellular variable-type immunoglobulin (IgV)-IgC domain, a signature intracellular domain, and an additional isoform, known as 4Ig-B7-H3, containing nearly exact tandem duplication of the IgV-IgC domain and most likely caused by exon duplication. B7-H3 mRNA is broadly expressed in normal tissues whereas its protein expression is relatively rare. The expression of B7-H3 is induced on T cells, natural killer (NK) cells, and antigen-presenting cells (APCs), including dendritic cells (DCs) and macrophages. It can be upregulated during the maturation from monocytes to DCs, or during the interaction between DCs and regulatory T cells. B7-H3 has been shown to be a co-stimulatory molecule that inhibits T-cell responses. B7-H3 has also been identified to bind TLT-2 involved in the intracellular signaling pathway.
Reactivity
Human
Host
Mouse
Conjugate
Red dye
Antibody clone number
MIH42
Vial size
100 tests
Storage
2°C-8°C
Handling
Ambient RT
CD276 protein structure - 351006 shown in red.