RHOH

The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

Description

Ras homolog family member H

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (40191053 - 40246967)

Ensembl ID

ENSG00000168421  (ver. 103.38)

Orthologs

Mouse Rhoh: ENSMUSG00000029204

UniProt

Q15669

neXtProt

NX_Q15669

Human splice variants
Mouse splice variants

Protein structure