329702

antibody from BioLegend

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Western blot

Immunohistochemistry

Antibody data

Submit

Validation data

Product number: 329702 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#329702, RRID:AB_940372
Product name: Purified anti-human CD274 (B7-H1, PD-L1)
Antibody type: Monoclonal
Antigen: Full length human PD-L1
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-g production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C."

CD274 protein structure - 329702 shown in red.