TASP1

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Description

Taspase 1

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (13389392 - 13638932)

Ensembl ID

ENSG00000089123  (ver. 103.38)

Orthologs

Mouse Tasp1: ENSMUSG00000039033

UniProt

Q9H6P5

neXtProt

NX_Q9H6P5

Human splice variants
Mouse splice variants

Protein structure