PNMA1

gene product
MA1
The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies. [supplied by OMIM, May 2010]
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87 antibodies from 14 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
11 antibodies
Atlas Antibodies
2 antibodies
Abnova Corporation
7 antibodies
antibodies-online
30 antibodies
LifeSpan BioSciences, Inc.
9 antibodies
Proteintech Group
1 antibody
Aviva Systems Biology
2 antibodies
Acris Antibodies GmbH
1 antibody
Creative Biomart
7 antibodies
Biorbyt
2 antibodies
United States Biological
8 antibodies
Sigma-Aldrich
4 antibodies
GeneTex
2 antibodies
GenWay
1 antibody