HLA-DQB1

gene product
CELIAC1, HLA-DQB, IDDM1
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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84 antibodies from 12 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
21 antibodies
Abnova Corporation
5 antibodies
Atlas Antibodies
1 antibody
BioLegend
5 antibodies
antibodies-online
13 antibodies
LifeSpan BioSciences, Inc.
3 antibodies
GeneTex
1 antibody
Aviva Systems Biology
14 antibodies
Creative Biomart
10 antibodies
Thermo Fisher Scientific Pierce
5 antibodies
RayBiotech, Inc.
2 antibodies
Sigma-Aldrich
4 antibodies