NBP2-34301-0.1mg

antibody from Novus Biologicals
Targeting: TNF DIF, TNF-alpha, TNFA, TNFSF2
Provider product page for NBP2-34301-0.1mg
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NBP2-34301-0.1mg - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal TNF-alpha Antibody
Antibody type
Monoclonal
Description
Protein A purified. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Reactivity
Human, Mouse, Rat, Canine, Feline, Rabbit, Zebrafish
Host
Mouse
Isotype
IgM
Vial size
0.1 mg
Concentration
0.2 mg/ml
Storage
Store at 4C.
TNF protein structure - NBP2-34301-0.1mg shown in red.