502925

antibody from BioLegend
Targeting: TNF DIF, TNF-alpha, TNFA, TNFSF2
Provider product page for 502925

Antibody data

Product number
502925 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#502925, RRID:AB_961433
Product name
PerCP/Cy5.5 anti-human TNF-‡
Antibody type
Monoclonal
Antigen
E. coli-expressed, recombinant human TNF-α
Description
TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
Reactivity
Human, Porcine, Simian
Host
Mouse
Conjugate
Far-Red dye
Isotype
IgG
Vial size
25 tests
Storage
The TNF-α antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
TNF protein structure - 502925 shown in red.