Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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Validation data
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- Product number
- 51001-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#51001-2-AP, RRID:AB_2122574
- Product name
- ICMT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ICMT antibody (Cat. #51001-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.
Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor.
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells.
Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
Ahearn IM, Court HR, Siddiqui F, Abankwa D, Philips MR
Life science alliance 2021 May;4(5)
Life science alliance 2021 May;4(5)
Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor.
Borini Etichetti C, Di Benedetto C, Rossi C, Baglioni MV, Bicciato S, Del Sal G, Menacho-Marquez M, Girardini J
The Journal of biological chemistry 2019 Mar 29;294(13):5060-5073
The Journal of biological chemistry 2019 Mar 29;294(13):5060-5073
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR
The Journal of cell biology 2017 Dec 4;216(12):4165-4182
The Journal of cell biology 2017 Dec 4;216(12):4165-4182
Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells.
Zhou HC, Fang JH, Luo X, Zhang L, Yang J, Zhang C, Zhuang SM
Oncotarget 2014 Dec 15;5(23):12177-88
Oncotarget 2014 Dec 15;5(23):12177-88
Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR
The Journal of clinical investigation 2013 Nov;123(11):4681-94
The Journal of clinical investigation 2013 Nov;123(11):4681-94
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