ZNF365

This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]

Description

Zinc finger protein 365

Tissue specificity

Tissue enhanced (brain, esophagus)

Subcell location

Vesicles, Centrosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

10 (62374192 - 62480288)

Ensembl ID

ENSG00000138311  (ver. 103.38)

Orthologs

Mouse Zfp365: ENSMUSG00000037855

UniProt

Q70YC5

neXtProt

NX_Q70YC5

Human splice variants
Mouse splice variants

Protein structure