CDCA4

This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

Description

Cell division cycle associated 4

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

14 (105009573 - 105021083)

Ensembl ID

ENSG00000170779  (ver. 103.38)

Orthologs

Mouse Cdca4: ENSMUSG00000047832

UniProt

Q9BXL8

neXtProt

NX_Q9BXL8

Human splice variants
Mouse splice variants

Protein structure