ZNF189

Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present. [supplied by OMIM, May 2010]

Description

Zinc finger protein 189

Tissue specificity

Tissue enhanced (epididymis)

Subcell location

Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

9 (101398873 - 101410660)

Ensembl ID

ENSG00000136870  (ver. 103.38)

Orthologs

Mouse Zfp189: ENSMUSG00000039634

UniProt

O75820

neXtProt

NX_O75820

Human splice variants
Mouse splice variants

Protein structure