CAPN6

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]

Description

Calpain 6

Tissue specificity

Group enriched (epididymis, placenta, seminal vesicle)

Subcell location

Nucleoplasm, Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (111245099 - 111270483)

Ensembl ID

ENSG00000077274  (ver. 103.38)

Orthologs

Mouse Capn6: ENSMUSG00000067276

UniProt

Q9Y6Q1

neXtProt

NX_Q9Y6Q1

Human splice variants
Mouse splice variants

Protein structure