613301

antibody from BioLegend

Targeting: H2AX H2AFX

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

613301

Provider

BioLegend

Proper citation

BioLegend Cat#613301, RRID:AB_315792

Product name

Purified anti-H2A.X

Antibody type

Polyclonal

Antigen

Recominant (partial), N-terminal

Description

H2A.X is a 14 kD basal histone and a member of the H2 histone family. This nuclear protein is synthesized in the G1 and S phase of the cell cycle and is known to be important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 after double-stranded DNA breaks. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability. The Poly6133 antibody has been shown to be useful for Western blotting and immunofluorescence of human H2A.X.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

50 µl

Storage

Upon receipt, store frozen at -20° C.

References

Submitted references

The nucleolus directly regulates p53 export and degradation.

Boyd MT, Vlatkovic N, Rubbi CP
The Journal of cell biology 2011 Sep 5;194(5):689-703

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The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability.

Li M, Xu X, Liu Y
Molecular and cellular biology 2011 May;31(10):2090-9

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Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.

Ramirez-Herrick AM, Mullican SE, Sheehan AM, Conneely OM
Blood 2011 Mar 3;117(9):2681-90

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gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?

Beels L, Bacher K, De Wolf D, Werbrouck J, Thierens H
Circulation 2009 Nov 10;120(19):1903-9