CTPS2

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

CTP synthase 2

Tissue specificity

Low tissue specificity

Subcell location

Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (16587999 - 16712936)

Ensembl ID

ENSG00000047230  (ver. 103.38)

Orthologs

Mouse Ctps2: ENSMUSG00000031360

UniProt

Q9NRF8

neXtProt

NX_Q9NRF8

Human splice variants
Mouse splice variants

Protein structure