Antibody data

Product number
362708 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#362708, RRID:AB_2564402
Product name
APC anti-human/mouse CD3ε (activation epitope)
Antibody type
Monoclonal
Antigen
Purified denatured CD3 proteins from human thymus
Description
The CD3ε chain of the CD3-TCR complex is a type I membrane protein that undergoes conformational change following ligation of the TCR-CD3 complex.  This conformational change leads to exposure of the proline rich sequence in CD3ε and results in recruitment of Nck. It is expressed by all mature T cells and forms a heteromeric complex with CD3 α/β or γ/δ and ζ chains. It is important in T cell development, and deficiency of this gene has been associated with severe immunodeficiency.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Red dye
Antibody clone number
APA1/1
Vial size
100 tests
Storage
2°C-8°C
Handling
Ambient RT
CD3E protein structure - 362708 shown in red.