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Western blot
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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-805-083-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-805-083-C100, RRID:AB_2051114
- Product name
- CEACAM6 (human) monoclonal antibody (9A6)
- Antibody type
- Monoclonal
- Antigen
- Purified from natural sources
- Description
- Protein G-affinity purified.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 9A6
- Vial size
- 100 μg
- Storage
- -20°C
- Handling
- For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20¡C.
Submitted references Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens.
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.
Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells.
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site.
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear factor-kappaB.
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells.
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas.
CEA-related proteins on human urothelial cell lines of different transformation grades.
Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers.
Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin.
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members.
Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants.
Biochemical characterization and tissue distribution of the Cora antigen, a cell surface glycoprotein differentially expressed on malignant and benign gastrointestinal epithelia.
Schmitter T, Agerer F, Peterson L, Munzner P, Hauck CR
The Journal of experimental medicine 2004 Jan 5;199(1):35-46
The Journal of experimental medicine 2004 Jan 5;199(1):35-46
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.
Singer BB, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Obrink B
Journal of immunology (Baltimore, Md. : 1950) 2002 May 15;168(10):5139-46
Journal of immunology (Baltimore, Md. : 1950) 2002 May 15;168(10):5139-46
Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells.
Muenzner P, Billker O, Meyer TF, Naumann M
The Journal of biological chemistry 2002 Mar 1;277(9):7438-46
The Journal of biological chemistry 2002 Mar 1;277(9):7438-46
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site.
Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA
Blood 2001 Sep 1;98(5):1469-79
Blood 2001 Sep 1;98(5):1469-79
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear factor-kappaB.
Muenzner P, Naumann M, Meyer TF, Gray-Owen SD
The Journal of biological chemistry 2001 Jun 29;276(26):24331-40
The Journal of biological chemistry 2001 Jun 29;276(26):24331-40
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells.
Muenzner P, Dehio C, Fujiwara T, Achtman M, Meyer TF, Gray-Owen SD
Infection and immunity 2000 Jun;68(6):3601-7
Infection and immunity 2000 Jun;68(6):3601-7
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas.
Schölzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B, Thompson J
The American journal of pathology 2000 Feb;156(2):595-605
The American journal of pathology 2000 Feb;156(2):595-605
CEA-related proteins on human urothelial cell lines of different transformation grades.
Krop-Watorek A, Laskowska A, Salwa J, Kłopocki AG, Grunert F, Ugorski M
Cancer letters 1999 May 3;139(1):15-22
Cancer letters 1999 May 3;139(1):15-22
Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers.
Wang J, Gray-Owen SD, Knorre A, Meyer TF, Dehio C
Molecular microbiology 1998 Nov;30(3):657-71
Molecular microbiology 1998 Nov;30(3):657-71
Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin.
Hanenberg H, Baumann M, Quentin I, Nagel G, Grosse-Wilde H, von Kleist S, Göbel U, Burdach S, Grunert F
Leukemia 1994 Dec;8(12):2127-33
Leukemia 1994 Dec;8(12):2127-33
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members.
Thompson J, Mössinger S, Reichardt V, Engels U, Beauchemin N, Kommoss F, von Kleist S, Zimmermann W
International journal of cancer 1993 Sep 9;55(2):311-9
International journal of cancer 1993 Sep 9;55(2):311-9
Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants.
Daniel S, Nagel G, Johnson JP, Lobo FM, Hirn M, Jantscheff P, Kuroki M, von Kleist S, Grunert F
International journal of cancer 1993 Sep 9;55(2):303-10
International journal of cancer 1993 Sep 9;55(2):303-10
Biochemical characterization and tissue distribution of the Cora antigen, a cell surface glycoprotein differentially expressed on malignant and benign gastrointestinal epithelia.
Göttlinger HG, Lobo FM, Grimm TW, Riethmüller G, Johnson JP
Cancer research 1988 Apr 15;48(8):2198-203
Cancer research 1988 Apr 15;48(8):2198-203
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Reactivity of FITC-labelled MAb to CEACAM6 (human) (9A6) (Prod. No. ALX-805-083) with polymorph nuclear cells. 2x10E5 polymorph nuclear cells (PMN) with (green) or without (blue) prior incubation with PMA were reacted for 30 min. at 4¡C with FITC conjugated MAb to CEACAM6 (human) (9A6) (40µg/ml) or with an isotype matched FITC-conjugated irrelevant MAb (red), then washed twice. PMN expression of CEACAM6 is constitutively and can be augmented by treatment with PMA.
