334312

antibody from BioLegend

Targeting: CD40 Bp50, p50, TNFRSF5

Antibody data

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Validation data

Product number: 334312 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#334312, RRID:AB_1186029
Product name: Alexa Fluor® 647 Anti-human CD40 [5C3]
Antibody type: Monoclonal
Antigen: CD40
Description: CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Red dye
Isotype: IgG
Vial size: 100 tests
Storage: The antibody solution should be stored undiluted at 4°C.

CD40 protein structure - 334312 shown in red.