303611

antibody from BioLegend

Targeting: CD40 Bp50, p50, TNFRSF5

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Supportive data in Antibodypedia)

Functional assay (Recommended by provider)

Antibody Data

Product number

303611

Provider

BioLegend

Product name

LEAF™ Purified anti-human CD40 [G28.5]

Antibody type

Monoclonal

Antigen

CD40

Description

CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The G28.5 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

1 mg

Concentration

1 mg/ml

Storage

The antibody solution should be stored undiluted at 4 °C.  This LEAF™ solution contains no preservative; handle under aseptic conditions.

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood lymphocytes stained with LEAF™ purified G28.5, followed by anti-mouse IgG FITC

Conjugate

Unconjugated