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Immunocytochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-805-046B-C050 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-805-046B-C050, RRID:AB_2051052
- Product name
- CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full length protein
- Description
- Protein G-affinity purified.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Biotin
- Isotype
- IgG
- Antibody clone number
- FGK45
- Vial size
- 50 μg
- Storage
- +4°C
- Handling
- Do not freeze. Protect from light.
Submitted references Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus.
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling.
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN.
IRF-7 is the master regulator of type-I interferon-dependent immune responses.
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes.
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system.
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells.
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process.
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity.
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.
Bartholdy C, Kauffmann SØ, Christensen JP, Thomsen AR
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1662-70
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1662-70
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling.
Hellings PW, Kasran A, Bullens D, Overbergh L, Mathieu C, Heremans H, Matthys P, Boon L, Jorissen M, Ceuppens JL
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):5138-44
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):5138-44
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN.
Greene JA, DeVecchio JL, Gould MP, Auletta JJ, Heinzel FP
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5995-6003
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5995-6003
IRF-7 is the master regulator of type-I interferon-dependent immune responses.
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T
Nature 2005 Apr 7;434(7034):772-7
Nature 2005 Apr 7;434(7034):772-7
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes.
McGregor CM, Schoenberger SP, Green EA
Proceedings of the National Academy of Sciences of the United States of America 2004 Jun 22;101(25):9345-50
Proceedings of the National Academy of Sciences of the United States of America 2004 Jun 22;101(25):9345-50
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system.
Erlebacher A, Zhang D, Parlow AF, Glimcher LH
The Journal of clinical investigation 2004 Jul;114(1):39-48
The Journal of clinical investigation 2004 Jul;114(1):39-48
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells.
Turner JG, Rakhmilevich AL, Burdelya L, Neal Z, Imboden M, Sondel PM, Yu H
Journal of immunology (Baltimore, Md. : 1950) 2001 Jan 1;166(1):89-94
Journal of immunology (Baltimore, Md. : 1950) 2001 Jan 1;166(1):89-94
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process.
Mauri C, Mars LT, Londei M
Nature medicine 2000 Jun;6(6):673-9
Nature medicine 2000 Jun;6(6):673-9
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity.
Rolink AG, Andersson J, Melchers F
European journal of immunology 1998 Nov;28(11):3738-48
European journal of immunology 1998 Nov;28(11):3738-48
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.
Rolink A, Melchers F, Andersson J
Immunity 1996 Oct;5(4):319-30
Immunity 1996 Oct;5(4):319-30
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Supportive validation
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- Enzo Life Sciences (provider)
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- Experimental details
- Two-color analysis of the expression of CD40 on mouse spleen cells. Splenocytes were simultaneously stained with APC-conjugated anti-B220 MAb and biotinylated FGK45 MAb to CD40 (Prod. No. ALX-805-046) followed by a streptavidin-R-PE conjugate. Specificity of FGK45 towards CD40 was confirmed on splenocytes from -/- CD40 mice and a biotin-conjugated isotype control.
